Mitochondria in cancer cells: what is so special about them?

By V. Gogvadze, S. Orrenius, B. Zhivotovsky. Trends in Cell Biology, 2008

632 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7019959c0287fef3e366d4ebdb3795e137eed430

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Guido Kroemer
2. L. Galluzzi
3. Linda Partridge
4. T. Seyfried
5. Laura M. Shelton
6. T. Niccoli
7. Simone Fulda

In Molecular Biology

1. L. Galluzzi
2. Guido Kroemer
3. Simone Fulda
4. Linda Partridge
5. T. Seyfried
6. Laura M. Shelton
7. T. Niccoli
8. Douglas R. Green

Citations in the corpus

• Targeting mitochondria for cancer therapy (2010, background): “As mitochondria are key regulators of cell death and as mitochondrial functions are often altered in neoplasi”
• Cancer as a metabolic disease (2010, background): “In addition to the six recognized hallmarks of cancer, aerobic glycolysis or the Warburg effect is also a robust metabolic hallmark of most tumors [10-14].”
• Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction (2009, neutral): “, 1999) and the downregulation of mitochondrial function (Gogvadze et al., 2008) in tumors can contribute to ROS generation.”
• Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy (2012, neutral): “The leakage of electrons from the electron transport chain during ATP synthesis results in the reduction of molecular oxygen to superoxide (100, 223).”
• Molecular mechanisms and physiological functions of mitophagy (2021, neutral): “Since accumulation of dysfunctional mitochondria is involved in tumorigenesis, it is conceivable that mitophagy seems to be important as a tumor-suppressive system (Gogvadze et al , 2008; Vara-Perez et al , 2019).”
• Ageing as a risk factor for disease. (2012, background): “The shift to glycolysis also makes the mitochondria more stable and less able to activate apoptosis, thus helping cancer cells to proliferate [73].”
• Mitochondrial dynamics regulates migration and invasion of breast cancer cells (2012, background): “Unbalanced mitochondrial fission or fusion events dysregulate key cellular processes, potentially contributing to tumorigenesis (18,19).”