Mechanisms and Functions of ATP-Dependent Chromatin-Remodeling Enzymes
By G. Narlikar, R. Sundaramoorthy, T. Owen-Hughes. Cell, 2013
633 citations recorded by the source corpus.
Chromatin provides both a means to accommodate a large amount of genetic material in a small space and a means to package the same genetic material in different chromatin states. Transitions between chromatin states are enabled by chromatin-remodeling ATPases, which catalyze a diverse range of structural transformations. Biochemical evidence over the last two decades suggests that chromatin-remodeling activities may have emerged by adaptation of ancient DNA translocases to respond to specific features of chromatin. Here, we discuss such evidence and also relate mechanistic insights to our understanding of how chromatin-remodeling enzymes enable different in vivo processes.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/b1e0d07a52572ec55b6cfdf8df36556389d5e93b
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- D. J. Clark
- P. Eriksson
- Brian D. Strahl
- Josefina Ocampo
- Scott B. Rothbart
- Răzvan V. Chereji
- C. D. Allis
- Yi Zhang
Citations in the corpus
- The ISW1 and CHD1 ATP-dependent chromatin remodelers compete to set nucleosome spacing in vivo (2016, background): “Mutations in subunits of human remodeling complexes occur at high frequency in many cancers (4) and are associated with developmental abnormalities (6).”
- Interpreting thelanguage of histone and DNA modifications (2014, background): “The degree to which chromatin is organized and packaged is highly influenced by numerous factors, including the actions of linker histone H1 that regulates the formation of higher-order chromatin states [6], histone variants that can be substituted for canonical histones in the nucleosome core parti”