mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.

By M. Frias, C. Thoreen, Jacob D. Jaffe, W. Schroder, T. Sculley, Steven A. Carr, David M. Sabatini. Current Biology, 2006

735 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6f215a3f0164349d07a3ae4735f378f32ab89c66

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. David M. Sabatini
2. M. Laplante
3. K. Guan
4. D. Klionsky
5. R. A. Saxton
6. T. Franke

In Molecular Biology

1. David M. Sabatini
2. M. Laplante
3. K. Guan
4. R. A. Saxton
5. Roberto Zoncu
6. T. Franke
7. D. Klionsky
8. D. Guertin

Citations in the corpus

• Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. (2006, result): “Recently, we found that mSIN1 is an additional component of mTORC2, and while this manuscript was under review, another study reported similar conclusions (Frias et al., 2006; Jacinto et al., 2006).”
• mTOR signaling at a glance (2009, background): “There is some evidence that Rictor and mSIN1 stabilize each other, establishing the structural foundation of mTORC2 ( Frias et al., 2006; Jacinto et al., 2006).”
• The mTOR Signalling Pathway in Human Cancer (2012, background): “In mammalian cells, mTORC2 phosphorylates AKT upon serum stimulation, namely growth factors such as insulin and IGF1 (insulin-like growth factor 1), suggesting that mTORC2 is regulated by the PI3K pathway [35,92].”
• Potential therapeutic applications of autophagy (2007, background): “TORC2 can be further subdivided into additional complexes based on alternative splicing of the mammalian stress-activated protein-kinase-interacting protein (SIN1”
• mTOR Signaling in Growth, Metabolism, and Disease (2017, background): “, 2009), aswell as the regulatory subunitsmSin1 (Frias et al., 2006; Jacinto et al., 2006; Yang et al., 2006) and Protor1/2 (Pearce et al.”
• mTOR signaling in growth control and disease (2012, positive): “Leading Edge Review mTOR Signaling in Growth”
• mTOR: from growth signal integration to cancer, diabetes and ageing (2010, background): “, whereas mTORC2 contains protein observed with RICTOR 1 (PROTOR1) and PROTOR2, which are likely to help complex assembly, and mammalian stress-activated map kinase-interacting protein 1 (mSIN1; also known as MAPKAP1), which may target mTORC2 to membrane”
• PI3K/Akt: getting it right matters (2008, background): “In further studies, siRNA knockdown of rictor, mTOR, mammalian LST8/G-protein b-subunit like protein (mLST8/GbL) and mammalian stress-activated protein kinase interacting protein 1 (mSIN1) as primary components of mTORC2 confirms its molecular identity: siRNA knockdown of any mTORC2 component inhibi”
• Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40 (2007, result): “The Sin1–mTOR interaction has also been identified in recent studies by other group”