Innate immunity of the newborn: basic mechanisms and clinical correlates

By O. Levy. Nature reviews. Immunology, 2007

1,236 citations recorded by the source corpus.

Subfields: Immunology, Nutrition and Dietetics, Obstetrics and Gynecology

View Paper: https://www.semanticscholar.org/paper/6d73c6f340db6ed4eb9aac7ce7d0237dd5b0f84d

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In Nutrition and Dietetics

In Obstetrics and Gynecology

Citations in the corpus

B-cell responses to vaccination at the extremes of age (2009, background): “Innate immune responses can be readily elicited at birth, although with specific characteristics (reviewed in Ref”
Microglia: active sensor and versatile effector cells in the normal and pathologic brain (2007, background): “The ability to respond to internal signals or foreign material as an innate immune cell is likely to undergo similar maturation [ 59 ].”
A Mouse Model for Chikungunya: Young Age and Inefficient Type-I Interferon Signaling Are Risk Factors for Severe Disease (2008, background): “Indeed, a number of physiological variables differentiate the neonatal and adult hosts, including the relative proportion of tissue fibroblasts, the rate of cell division, and the maturity and effectiveness of the innate immune system [33].”
Immunological mechanisms of vaccination (2011, background): “, and it is known that the neonatal innate immune system, which is biased against the production of proinflammatory cytokines, impairs responses to many vaccine”
Human breast milk: A review on its composition and bioactivity. (2015, background): “Further regulation by soluble tolllike receptor 2 (sTLR-2), which regulates cell activation via cell surface TLR-2, has also been noted in breast milk but not in infant formula [8].”
Trained immunity: a program of innate immune memory in health and disease (2016, background): “It is also likely that trained immunity plays an important role in ontogeny, enabling the maturation of the innate immune system of the newborn (97), a process in which microbiota plays an important role (98).”
IgG Placental Transfer in Healthy and Pathological Pregnancies (2011, background): “and cationic membrane-active APPs, such as lactoferrin, bactericidal/permeability-increasing protein, histones, and defensins [2].”
Adverse childhood experiences, allostasis, allostatic load, and age-related disease. (2012, background): “In addition to this passive immunity, newborns' adaptation in the face of infection relies upon the activity of their innate immune system [51].”
Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species (2013, background): “Systemically, the immune response of human neonates differs from the adult, with a bias towards Th2 responses as well as higher productionofIL-1 and IL-10 from peripheral blood monocytes after stimulation with pathogens (Levy, 2007).”
Macrophages are required for neonatal heart regeneration. (2014, neutral): “In mice, the adaptive immune response does not begin to mature until 3 weeks of age (7–13), and the innate immune response is quantitatively and qualitatively different in the early neonate and adult (14–17).”
Farm living: effects on childhood asthma and allergy (2010, background): “Studies have shown that human adaptive immune responses (of both the T H 1 and the T H 2 type) are typically immature and suppressed at birt”