Macrophages are required for neonatal heart regeneration.

By A. Aurora, E. Porrello, W. Tan, A. Mahmoud, Joseph A. Hill, R. Bassel-Duby, Hesham A. Sadek, E. Olson. Journal of Clinical Investigation, 2014

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The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis. (2016, background): “Recently, neonatal macrophage subsets have been suggested to activate a regenerative program in the infarcted myocardium.(267) Moreover, certain chemokines (such as stromal cell–derived factor-1/CXCL12), cytokines, and growth factors may regulate trafficking, activation, differentiation, and surviva”
Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration (2016, background): “Collagens can be further cross-linked enzymatically by lysyl oxidases (LOX) or by a reduction in the response to the formation of advanced glycation end-products (AGEs).”
Pathophysiology of Myocardial Infarction (2015, neutral): “polarization of neonatal macrophages (13).”
Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart (2014, background): “The concept that distinct macrophage subsets and lineages populate the injured neonatal and adult heart provides a mechanistic basis to explain why the neonatal and adult heart demonstrate different responses to injury and is consistent with and expands on the findings of Aurora and colleagues (14),”