Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species
By B. Semple, K. Blomgren, Kayleen Gimlin, D. Ferriero, L. Noble‐Haeusslein. Progress in neurobiology, 2013
1,942 citations recorded by the source corpus.
Hypoxic-ischemic and traumatic brain injuries are leading causes of long-term mortality and disability in infants and children. Although several preclinical models using rodents of different ages have been developed, species differences in the timing of key brain maturation events can render comparisons of vulnerability and regenerative capacities difficult to interpret. Traditional models of developmental brain injury have utilized rodents at postnatal day 7–10 as being roughly equivalent to a term human infant, based historically on the measurement of post-mortem brain weights during the 1970s. Here we will examine fundamental brain development processes that occur in both rodents and humans, to delineate a comparable time course of postnatal brain development across species. We consider the timing of neurogenesis, synaptogenesis, gliogenesis, oligodendrocyte maturation and age-dependent behaviors that coincide with developmentally regulated molecular and biochemical changes. In general, while the time scale is considerably different, the sequence of key events in brain maturation is largely consistent between humans and rodents. Further, there are distinct parallels in regional vulnerability as well as functional consequences in response to brain injuries. With a focus on developmental hypoxicischemic encephalopathy and traumatic brain injury, this review offers guidelines for researchers when considering the most appropriate rodent age for the developmental stage or process of interest to approximate human brain development.
Subfields: Epidemiology, Neurology, Pediatrics, Perinatology and Child Health
View Paper: https://www.semanticscholar.org/paper/6926cbb2741aaa90cf72d7d703fd2437fd8c7650
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Citations in the corpus
- The gut microbiota mediates the anti-seizure effects of the ketogenic diet (2018, neutral): “…to early human brain development, where neurodevelopmental milestones in 3-week old mice are comparable to those of the 2-3 year old human brain (Semple et al., 2013), and iii) preclude pre-weaning dietary treatment, where effects of the diet on maternal behavior and physiology would confound…”
- The Cellular and Molecular Landscapes of the Developing Human Central Nervous System (2016, neutral): “Indicative of the biological challenge of precisely regulating diverse molecular and cellular processes over a protracted period of time and across myriad cell types and regions, the CNS exhibits regionally and temporally distinct patterns of vulnerability to various diseases and insults (Figure 2) ”
- The Central Nervous System and the Gut Microbiome (2016, background): “Major Events in Mammalian Brain Development Developmental trajectories and key neurodevelopmental events in mice and humans (adapted from Knuesel et al., 2014; Pressler and Auvin, 2013; Semple et al., 2013).”