Circulating endothelial progenitor cells, vascular function, and cardiovascular risk.

By J. Hill, G. Zalos, J. Halcox, W. Schenke, M. Waclawiw, A. Quyyumi, Toren Finkel. New England Journal of Medicine, 2003

3,619 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6d1be4a232a48bf2aa6321b310aaeb3bf3ccb5cf

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In Molecular Biology

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7. Shahin Rafii
8. M. Schneider

Citations in the corpus

• Impaired progenitor cell activity in age-related endothelial dysfunction. (2005, background): “Recently, Hill et al. ( 16 ) described the correlation between the number of EPC colonies after one week of culture, as an equivalent for the level of circulating EPCs, with the brachial artery reactivity as an index of endothelial function.”
• Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus. (2005, positive): “Circulating EPC and CPC reduction has been demonstrated in several clinical conditions characterized by high cardiovascular risk (11–14), although data on stable atherosclerotic disease are few and ambiguous.”
• Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1 (2004, background): “, and these cells are the most widely studied type of vascular progenitor cel”
• Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis (2010, background): “Preserved brachial FMD is strongly associated with an increased number of endothelial progenitor cells regardless of Framingham risk scores [ 32 ].”
• Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease (2013, positive): “derived-endothelial progenitor cells (EPCs) and so the concentration of these in the plasma reflects the endothelial repair capacity [87].”
• Unchain my heart: the scientific foundations of cardiac repair. (2005, background): “578 The Journal of Clinical Investigation http://www.jci.org Volume 115 Number 3 March 2005 of tumor angiogenesis focused on in vivo homing by embryonic EPCs from cord blood, the circulating cells arrested within tumor microvessels, extravasated into the interstitium, and incorporated into neovessel”
• The Tissue-Engineered Vascular Graft—Past, Present, and Future (2015, background): “Vascular EPCs may be depleted in elderly patients, thus making them potentially difficult to obtain.(183)”
• Reduced Number of Circulating Endothelial Progenitor Cells Predicts Future Cardiovascular Events: Proof of Concept for the Clinical Importance of Endogenous Vascular Repair (2005, neutral): “Family history 6 (14) 16 (36) 13 (39) Co vs CAD and ACS, 0.”
• Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target? (2019, background): “The importance of the balance between exposure to risk factors and the efficiency of endothelial repair has been underscored by the observation that subjects with increased numbers of circulating endothelial progenitor cells have preserved endothelial function, despite exposure to high levels of ris”
• The pathobiology of vascular dementia (2013, positive): “EPC are reduced by stroke risk factors (Hill et al., 2003) and predict cardiovascular morbidity and mortality (Werner et al., 2005).”
• Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. (2007, neutral): “The assay mix contained the following probes and primers: (1) forward primer: 5 -AAGCTTTCTCACAAGCATTTGGTTT-3 ; (2) reverse primer: 5 -AGAAAGGCATTAGAAAGCCTGTAGTT-3 ; (3) VIC-labeled oligo: 5 -TCTCCACAGACACATAC-3 ; (4) FAM-labeled oligo: 5 -TCCACAGAAACATAC-3 .”
• Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes. (2004, neutral): “It was recently reported that a strong inverse correlation exists between the number of EPCs and the subjects’ combined Framingham risk factor score (9).”