Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition?

By Erik W. Thompson, D. Newgreen, D. Tarin. Cancer Research, 2005

678 citations recorded by the source corpus.

Subfields: Oncology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/6d0d8e8243d281a20da4ec8d758d5ef5d7bdd307

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. Jing Yang
2. M. Nieto
3. A. Cano
4. G. Moreno-Bueno
5. J. Tsai
6. M. Maeda
7. Erik W. Thompson
8. F. Portillo

In Pulmonary and Respiratory Medicine

1. Harikrishna Nakshatri
2. Erik W. Thompson
3. P. Chiarugi

Citations in the corpus

• NF-κB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2 (2007, background): “MCF10A/p65 cells were phenotypically similar to cells that have undergone epithelial to mesenchymal transition (EMT) although the concept of EMT in cancer is controversial (Tarin et al., 2005; Thompson et al., 2005).”
• Motility-driven glass and jamming transitions in biological tissues (2015, background): “In many of these processes, tissues undergo an Epithelialto-Mesenchymal Transition (EMT), where cells in a solidlike, well-ordered epithelial layer transition to a mesenchymal, migratory phenotype with less well-ordered cell-cell interactions [52, 53], or an inverse process, the Mesenchymalto-Epithe”
• Cadherin switching (2008, background): “The idea of EMTs, and their role in development and/or tumor progression, is controversial, but in some ways the controversy is a matter of semantics (Tarin et al., 2005; Thompson et al., 2005).”
• AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective (2010, neutral): “This controversy is extended by the rarity of EMT-like morphological changes in primary tumors and the observation that metastases are histologically and molecularly similar to the primary tumor.”
• Transcriptional regulation of cell polarity in EMT and cancer (2008, background): “Indeed, the relevance of EMT in human tumours is still a matter of considerable debate (Tarin et al., 2005; Thompson et al., 2005; Christiansen and Rajasekaran, 2006; Scheel et al., 2007; Talmadge, 2007), and some of these considerations await clarification and the development of appropriate in…”
• Anoikis: an emerging hallmark in health and diseases (2012, background): “Hence, due to their high mobility, mesenchymal cells are usually more resistant to anoikis [46,47].”
• Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. (2012, background): “However, the involvement of EMT in tumor metastasis in vivo is still hotly debated (Garber, 2008; Ledford, 2011; Tarin et al., 2005; Thompson et al., 2005).”
• Epithelial—mesenchymal and mesenchymal—epithelial transitions in carcinoma progression (2007, background): “This has led to controversy and healthy debate (Tarin et al., 2005; Thompson et al., 2005), and remains an important issue for the field.”
• Mathematical modelling of cancer cell invasion of tissue (2005, background): “This loss of compactness differentiates malignant and benign tumours and seems to be a biological process similar to the epithelial-mesenchymal transition in embryogenesis [5] [6] where a well organized and bipolar layer of cells becomes more diffuse and semidetached.”