Regulation of Cadherin Adhesive Activity

By B. Gumbiner. Journal of Cell Biology, 2000

807 citations recorded by the source corpus.

Adhesive interactions between cells are dynamic and regulated during tissue development and homeostasis. Cadherins are major cell–cell adhesion molecules involved in the development and maintenance of all solid tissues ([Takeichi 1991][1]; [Gumbiner 1996][2]). Therefore, regulation of cadherin-

Subfields: Molecular Biology

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EMT, the cytoskeleton, and cancer cell invasion (2009, background): “Destabilization of the E-cadherin adhesion complex is also accomplished by receptor tyrosine kinase or Srcmediated phosphorylation of E-cadherin, followed by its ubiquitylation by the E3 ligase Hakai and subsequent degradation [57, 58] (Fig.”
Leaving the neighborhood: molecular mechanisms involved during epithelial‐mesenchymal transition (2001, background): “(79) Condensing mesenchymal cells further differentiate within epithelial tubular cells expressing high levels of E-cadherin.”
α-Catenin Is a Molecular Switch that Binds E-Cadherin-β-Catenin and Regulates Actin-Filament Assembly (2005, neutral): “The intracellular domain of cadherins binds cytoplasmic proteins that are thought to recruit and organize actin filaments (Gumbiner, 2000; Jamora and Fuchs, 2002).”
Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions. (2013, background): “In both tight junctions and adherens junctions, adhesion is mediated by homophylic interactions between adhesion proteins that form complexes at sites of cell-to-cell contacts organized in zipper-like structures along the entire cell-to-cell contact border (Cavey et al., 2008; Gumbiner, 2000; Tsukit”
Biological Physics of the Developing Embryo (2005, neutral): “It treats bond formation as a simple chemical reaction (between the members of the encounter complex), whereas in reality it is an intricate multistep process (Adams et al., 1996, 1998; Gumbiner, 2000).”
Intercellular adhesion, signalling and the cytoskeleton (2002, background): “Indeed, the rate-limiting step in the formation of the adhesion junction complex seems to be the level of cadherin expressio”
Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development. (2002, background): “These include 1) guanosine nucleotide exchange factors (GEF), which facilitate the activation of GTPases by promoting the binding of GTP onto GTPases (for reviews, see Refs.”
Links between signal transduction, transcription and adhesion in epithelial bud development (2003, background): “Cadherins form the transmembrane core of adherens junctions (AJs) by bridging to α-catenin and the cytoskeleton through β-catenin, a protein which on its own is prone to degradatio”
Deconstructing the cadherin-catenin-actin complex. (2005, neutral): “The extracellular domain forms homo- and heterophilic bonds with cadherins on adjacent cells, which specify cell-cell recognition and sorting of mixtures of cells (Gumbiner, 2000; Foty and Steinberg, 2005).”