miRNAs, cancer, and stem cell division.

By Carlo Maria Croce, George A. Calin. Cell, 2005

1,384 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6cc37e3a81becee015d9e7f34d2c90635a77a173

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Citations in the corpus

MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells (2009, neutral): “MicroRNAs (miRNAs) are a conserved class of non-coding 20–22 nt small RNAs that regulate gene and protein expression by binding to mRNA leading to mRNA degradation or inhibition of translation”
miR-21-mediated tumor growth (2007, background): “As a new layer of gene regulation mechanism, miRNAs have diverse functions, including the regulation of cellular differentiation, proliferation and apoptosis (Chen et al., 2004; Croce and Calin, 2005).”
The Role of MicroRNAs in Human Diseases (2010, background): “MicroRNAs have been been demonstrated to play a major role in a wide range of developmental processes including metabolism, cell proliferation, apoptosis, developmental timing, and neuronal cell fate (15, 41 - 44) .”
Plant microRNA: a small regulatory molecule with big impact. (2006, background): “, 2005), stress response (Ambros, 2003), and carcinogenesis (Iorio et al., 2005; Croce and Calin, 2005).”
MicroRNAs: Novel Regulators Involved in the Pathogenesis of Psoriasis? (2007, background): “. Indeed, miRNAs have regulatory roles in development, differentiation, organogenesis, stem cell and germline proliferation, growth control and apoptosis. Moreover, deregulation of miRNA expression may contribute to human diseases; in particular, miRNAs are often aberrantly expressed or mutated in c”
Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation (2014, background): “They represent one of the most exciting areas of modern medical sciences as they possess unique ability to modulate an immense and complex regulatory network of gene expression [6, 7] in a broad spectrum of developmental and cellular processes including tissue development [8, 9], cell proliferation ”
A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. (2006, background): “Early studies suggested only a limited role for RNAi but the subsequent discovery of many endogenously encoded microRNAs (Lagos-Quintana et al., 2001, 2003; Lee and Ambros, 2001) pointed toward the possibility of this being a more general control mechanism (Hobert, 2004).”
MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. (2008, background): “…profiles in the diagnosis/prognosis of specific cancers and to distinguish certain cancer types (Calin et al. 2004, 2005; Takamizawa et al. 2004; Eis et al. 2005; Iorio et al. 2005; Lu et al. 2005). miRNAs have been reported to be involved in tumorigenesis, acting, as one might expect,…”
Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. (2006, background): “A strong link between miRNA and cancer has recently been demonstrated, opening up a new area of investigation in the field of cancer biology (reviewed by Croce and Calin, 2005).”
Micro-RNA profiling in kidney and bladder cancers. (2007, background): “Micro-RNA verexpression could also result in down-regulation of tuor suppressor genes, whereas their underexpression could ead to oncogene up-regulation [5,6].”