Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects.

By M. Höckel, P. Vaupel. Journal of the National Cancer Institute, 2001

2,681 citations recorded by the source corpus.

Subfields: Biotechnology, Cancer Research, Neurology

View Paper: https://www.semanticscholar.org/paper/6c70b98add72efaae8670b5183983be403de59ae

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biotechnology

1. Dai Fukumura
2. D. Ron
3. P. Vaupel
4. G. Semenza
5. P. Storz
6. N. Denko
7. Zena Werb
8. M. Egeblad

In Cancer Research

1. G. Semenza
2. Dai Fukumura
3. Rakesh K. Jain
4. Zena Werb
5. P. Vaupel
6. Adrian L. Harris
7. P. Ratcliffe
8. N. Denko

In Neurology

1. G. Semenza
2. P. Storz
3. N. Denko
4. Zena Werb
5. M. Egeblad
6. E. Nakasone
7. Adrian L. Harris
8. J. Tatum

Citations in the corpus

• Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy (2006, background): “There appears to be a vicious circle (Hockel & Vaupel 2001a, Hockel & Vaupel 2001b) in which hypoxia-induced changes promote malignant progression and increased aggressiveness, leading to tumor propagation and further tumor hypoxia.”
• Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response. (2004, background): “Evidence from recent studies suggests that sustained (>6-8 hours) or fluctuating hypoxic stress (pO2 ≤7 mmHg) can lead to alterations (stimulation or inhibition) of gene expression, as well as posttranscriptional and posttranslational modulations that result in changes in the tumor cell proteome (Fi”
• Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. (2016, background): “%) is estimated to represent a critical PO2 since lower PO2 values are associated with adverse effects caused by reduced O2 consumption (Hockel & Vaupel, 2001).”
• Photoacoustic imaging in cancer detection, diagnosis, and treatment guidance (2011, background): “Hypoxia is often linked to malignancy and resistance to therapy [32].”
• ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth (2005, background): “The development of fluctuating hypoxic and anoxic regions in tumors has profound consequences for malignant progres- sion, response to therapy and overall patient survival (Hockel and Vaupel, 2001).”
• The role of hypoxia-induced factors in tumor progression. (2004, background): “It has also been suggested that hypoxia exerts a strong selection pressure on malignant cells [5, 6 , 51, 52].”
• Detection and Characterization of Tumor Hypoxia Using pO2 Histography (2007, neutral): “In this discussion of hypoxic thresholds, it is important to note that, for any particular functional parameter, a sharp threshold between “hy-poxia” ( i.e. , more hypoxic tumors) and “normoxia” ( i.e. , less hypoxic tumors) does not exist and should not be expected (51).”
• Reactive oxygen species in tumor progression. (2005, background): “This adaptation of tumor cells to hypoxia contributes to the malignant phenotype and to aggressive tumor progression (27), and low oxygen tension in tumors is associated with increased metastasis and poor survival of patients in several squamous tumors (28, 29).”
• The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress (2016, background): “The uncontrolled growth of tumor cells forming an enlarging mass causes the distance between existing blood vessels to increase and creates areas of acute and chronic hypoxia [27].”