Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response.

By P. Vaupel, L. Harrison. The Oncologist, 2004

778 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Biotechnology, Cancer Research

View Paper: https://www.semanticscholar.org/paper/0ec93049493d580ea9f31a199d96595799f15c52

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. M. Höckel
2. A. Mayer
3. P. Vaupel

In Biotechnology

1. P. Vaupel
2. A. Mayer
3. M. Höckel
4. G. Semenza

In Cancer Research

1. A. Mayer
2. P. Vaupel
3. M. Höckel
4. Abdel Kareem Azab
5. F. Azab
6. Barbara Muz
7. Pilar de la Puente
8. G. Semenza

Citations in the corpus

• The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy (2015, background): “Tumor hypoxia develops due to uncontrollable cell proliferation, altered metabolism, and abnormal tumor blood vessels resulting in reduced transport of oxygen and nutrients.(13) Hypoxia is one of the main features of solid tumors and was shown to correlate with poor prognosis of cancer patients.”
• The role of hypoxia-induced factors in tumor progression. (2004, background): “Although some of the effects of hypoxia negatively impact tumor cell growth [ 7 ], they may, antithetically, lead to hypoxia-driven responses that enhance malignant progression and aggressiveness, ultimately resulting in increased resistance to therapy and a poor long-term prognosis.”
• Combination therapy in combating cancer (2017, background): “This abnormal growth pattern consequently results in a large diffusion distance between nutritive blood vessels [62].”
• Detection and Characterization of Tumor Hypoxia Using pO2 Histography (2007, positive): “In addition to enlarged diffusion distances, an adverse diffusion geometry ( e.g. , concurrent vs. countercur-rent tumor microvessels) can also cause hypoxia (130).”
• Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications (2019, background): “Hypoxia, which resulted from tumor cells with a status of vigorous metabolism and rapid growth but poorly organized vasculature, is a common feature occurring in the majority of solid tumors [58].”