The role of hypoxia-induced factors in tumor progression.

By P. Vaupel. The Oncologist, 2004

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Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway and its Potential for Therapeutic Intervention in Malignancy and Ischemia (2007, background): “During hypoxia, HIF-1 binds the regulatory region of the VEGF gene, inducing its transcription and initiating its expression [12,15,16].”
Role of tumor-associated macrophages in tumor progression and invasion (2006, background): “The transcription factor hypoxia-inducible factor-1 (HIF-1) is a major regulator of cell adaptation to hypoxic stress [33] and therefore a potential target for anticancer therapies [34].”
Detection and Characterization of Tumor Hypoxia Using pO2 Histography (2007, neutral): “125, 128, 139).”