Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis

By D. Sorescu, Daiana Weiss, B. Lassègue, R. Clempus, K. Szöcs, G. Sorescu, Liisa Valppu, M. Quinn, J. Lambeth, J. Vega and 2 more. Circulation, 2002

904 citations recorded by the source corpus.

Subfields: Immunology, Inorganic Chemistry, Physiology

View Paper: https://www.semanticscholar.org/paper/6b9dc44f9f77ab5531d7fa65fd0938fe741acec5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. J. Lambeth
2. B. Lassègue
3. R. Clempus
4. A. Shah
5. Jian-Mei Li
6. Rhian M. Touyz
7. E. Schiffrin
8. K. Griendling

In Inorganic Chemistry

1. J. Lambeth

In Physiology

1. J. Lambeth
2. R. Clempus
3. B. Lassègue
4. A. Shah
5. Jian-Mei Li
6. Rhian M. Touyz
7. K. Griendling
8. E. Schiffrin

Citations in the corpus

• Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. (2007, background): “Oxidative stress has been recognized as an important contributor to hypertensive disease since the mid 1990’s [62], although the major source of ROS has only more recently been proven to be Nox enzymes [63].”
• Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations. (2004, methodology): “Finally, as with the use of any fluorophore for tissue localization of the compound of interest, the potential for autofluorescence must be recognized and taken into account (120).”
• Vascular NAD(P)H oxidases: specific features, expression, and regulation. (2003, methodology): “using assays such as the inhibition of aconitase (14) and dihydroethidium staining (14, 40, 103, 129, 148, 181, 188).”
• Increased oxidative stress in obesity and its impact on metabolic syndrome. (2004, background): “The expression of NOX4 was not detected in macrophages (57, 58).”
• Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. (2004, background): “Consistent with these data, studies on diseased human coronary arteries have shown evidence of increased NADPH oxidase subunit expression together with increased in situ O2 generation in the plaque shoulder area (142).”
• Reactive oxygen species in vascular biology: implications in hypertension (2004, neutral): “Of particular importance, with respect to hypertension, is Ang II, which stimulates activation of NAD(P)H oxidase, increases expression of NAD(P)H oxidase subunits, and induces ROS production in cultured VSMCs, endothelial cells, adventitial fibroblasts (Lassegue and Clempus 2003), and in intact art”
• Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. (2018, background): “Under physiological conditions, superoxide anion production and subsequently H2O2 generation promote angiogenesis, migration, proliferation and survival of endothelial cells via ROSmediated p38 MAPK and Akt activation, whereas under conditions of excessive oxidative stress, the NOX4-generated ROS in”