Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

By T. Junt, E. Moseman, M. Iannacone, Steffen Massberg, Philipp A. Lang, M. Boes, K. Fink, S. Henrickson, D. Shayakhmetov, Nelson C. Di Paolo and 4 more. Nature, 2007

859 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/6b68408aa26d010e23d909e9c600229668364884

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In Immunology

1. P. Murray
2. TA Wynn
3. A. Mildner
4. Steffen Jung
5. D. Irvine
6. C. Varol
7. L. Chávez-Galán
8. G. Jennings

Citations in the corpus

• The who, how and where of antigen presentation to B cells (2009, background): “A crucial and newly described role for subcapsular-sinus macrophages in the presentation of antigen to follicular B cells has been recently established by three independent studie”
• Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction (2012, background): “ICMVs, synthesized by forming covalent cross-links across lipid layers within multilayered lipid vesicles, are stable in the extracellular milieu following injection and retain entrapped proteins until the particles are internalized into intracellular compartments, thereby increasing the delivery of”
• Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages (2012, background): “In the past few years, a CD169+ population of cells located in the subcapsular region of LNs was interpreted to represent a novel subtype of macrophage that captures and preserves extracellular antigen for presentation to B cells (Junt et al., 2007; Phan et al., 2009).”
• Much More than M1 and M2 Macrophages, There are also CD169+ and TCR+ Macrophages (2015, methodology): “Finally, SCS macrophages, as splenic CD169+ macrophages, require lymphotoxin alpha (LT-α) signaling and can be depleted using clodronate liposomes (141, 142).”
• Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer. (2012, background): “lymph node, carrying different sized particles to different regions and in turn helping to regulate appropriate immune responses to different types of stimuli (225, 253, 392, 432) (see also section VD).”
• Bio-inspired, bioengineered and biomimetic drug delivery carriers (2011, background): “The size of pathogens also regulates, in part, their dissemination in vivo ; viral particles that are small enough to diffuse freely through the extracellular matrix are drained rapidly from the peripheral tissue sites to lymph nodes, where primary immune responses are generate”
• Macrophages: development and tissue specialization. (2015, background): “Abbreviations: CDP, common dendritic cell precursor; cMoP, common monocyte progenitor; DC, dendritic cell; GMP, granulocyte/macrophage precursor; MDP, macrophage (monocyte)/dendritic cell precursor; PDC, plasmacytoid DC. Differential monocyte fates in tissues (i.e., effector monocytes and monocyte-d”
• Protective and pathogenic functions of macrophage subsets (2011, background): “, and subcapsular sinus macrophages of lymph nodes (LNs), which clear viruses from the lymph and initiate antiviral humoral immune response”
• Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns (2010, background): “By contrast, larger antigens, such as viruses and immune complexes , are initially captured by subcapsular sinus macrophages and subsequently shuttled to B cells, which transport the antigens to follicular DCs (FDCs) located in B cell follicle”