Repression of the human dihydrofolate reductase gene by a non-coding interfering transcript

By Igor Martianov, A. Ramadass, Ana Serra Barros, Natalie Chow, A. Akoulitchev. Nature, 2007

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View Paper: https://www.semanticscholar.org/paper/6b3b4422eb3dd304037ae93b678e3ac42c7cfe5b

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In Molecular Biology

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Induced ncRNAs Allosterically Modify RNA Binding Proteins in cis to Inhibit Transcription (2008, background): “S5b), while the N-terminus (1-211) interacted with CBP (Fig.”
On the classification of long non-coding RNAs (2013, background): “…60,61 ] to plants [e.g., COLDAIR (cold assisted intronic noncoding RNA) 62 ] to mammals [e.g., DHFR (dihydrofolate reductase) upstream transcripts, 23,63 Xist (X inactive-specific transcript) 64 ] in the mouse genome 49 and ~32% of the human lncRNAs are antisense to coding genes, 4 suggesting…”
A large intergenic non-coding RNA induced by p53 mediates global gene repression in the p53 response (2010, background): “Various possibilities include that (1) lincRNA-p21 might direct a protein complex to specific loci by Crick-Watson base pairing; (2) lincRNAs might act by forming DNA-DNA-RNA triple-helical structures, which do not require Crick-Watson base-pairing, such as reported for a large noncoding RNA that fo”
Evolution and functions of long noncoding RNAs. (2009, background): “In contrast to protein-coding genes, there- transcription from the major DHFR promoter (Martianov et al., 2007).”
Genomic maps of lincRNA occupancy reveal principles of RNA-chromatin interactions (2011, background): “…GA-rich HOTAIR motif may enable formation of RNA:DNA:DNA triplex (facilitated by homopurine runs and known mediate some lncRNAchromatin interaction [Martianov et al., 2007; Schmitz et al., 2010]), serve as the binding site of a protein that recruits HOTAIR, or indirectly configure a chromatin…”
Genome regulation by long noncoding RNAs (2012, background): “TFIIB DHFR minor Titrates away TFIIB during cell quiescence to decrease DHFR transcription (99)”
Circular intronic long noncoding RNAs. (2013, background): “, 2008) andDHFR (Martianov et al., 2007) mediate transcription suppression by targeting transcription initiationmachineries.”
Long non-coding RNAs: a new frontier in the study of human diseases. (2013, background): “This lncRNA acts as a repressor by forming an RNA–DNA triplex in the major promoter of DHFR and preventing the binding of the transcriptional co-factor TFIID [84].”
Long Noncoding RNAs: Past, Present, and Future (2013, background): “…through direct binding with the general transcription factor TFIIB, as well as possibly through DNA:RNA triplex formation at the major promoter (Martianov et al. 2007). lncRNAs transcribed from SINEs, an abundant class of retrotransposons that includes B2 in mice and Alu in humans, may also…”