Neuronal Diversity and Temporal Dynamics: The Unity of Hippocampal Circuit Operations

By T. Klausberger, Péter Somogyi. Science, 2008

2,066 citations recorded by the source corpus.

In the cerebral cortex, diverse types of neurons form intricate circuits and cooperate in time for the processing and storage of information. Recent advances reveal a spatiotemporal division of labor in cortical circuits, as exemplified in the CA1 hippocampal area. In particular, distinct GABAergic (γ-aminobutyric acid–releasing) cell types subdivide the surface of pyramidal cells and act in discrete time windows, either on the same or on different subcellular compartments. They also interact with glutamatergic pyramidal cell inputs in a domain-specific manner and support synaptic temporal dynamics, network oscillations, selection of cell assemblies, and the implementation of brain states. The spatiotemporal specializations in cortical circuits reveal that cellular diversity and temporal dynamics coemerged during evolution, providing a basis for cognitive behavior.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/6ac3b4840115b317dc3056b260ab4072132ce0bd

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Citations in the corpus

Independent control of gamma and theta activity by distinct interneuron networks in the olfactory bulb (2014, neutral): “as on slower, theta time scales 7 .”
Three Groups of Interneurons Account for Nearly 100% of Neocortical GABAergic Neurons (2011, background): “…the excitatory and inhibitory balance necessary for the transfer of information while preventing runaway excitation (McBain and Fisahn, 2001; Pouille and Scanziani, 2001; Wehr and Zador, 2003; Markram et al., 2004; Trevelyan et al., 2006; Klausberger and Somogyi, 2008; Haider and McCormick, 2009).”
Neurophysiological and Computational Principles of Cortical Rhythms in Cognition (2010, methodology): “The juxtacellular recording technique applied to gamma rhythm revealed that, in CA1, dendrite-targeting bistratified cells (rather than perisoma-targeting basket cells) exhibited the strongest modulation by field oscillations (511, 982).”
Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus (2013, background): “Interneuron networks provide general inhibition to balance excitation and they temporally and spatially regulate the activity of principal neurons (12, 13).”
The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors (2010, background): “There is increasing evidence that the high diversity of GABAergic interneurons underpins the functional complexity needed for neural computation (McBain and Fisahn, 2001; Klausberger and Somogyi, 2008).”
Receptive field formation by interacting excitatory and inhibitory synaptic plasticity (2016, background): “In part, this is likely due to the diversity of inhibitory cell types (Markram et al., 2004; Klausberger & Somogyi, 2008; DeFelipe et al., 2013) and their largely unresolved functional roles.”
COORDINATION OF SIZE AND NUMBER OF EXCITATORY AND INHIBITORY SYNAPSES RESULTS IN A BALANCED STRUCTURAL PLASTICITY ALONG MATURE HIPPOCAMPAL CA1 DENDRITES DURING LTP (2011, background): “These synapses are made by multiple types of interneurons that modulate or inhibit pyramidal cell excitability (Freund and Buzsaki, 1996; Gaiarsa et al., 2002; Klausberger and Somogyi, 2008).”
How Inhibition Shapes Cortical Activity (2011, neutral): “…being worked out with unprecedented detail (Ascoli et al., 2008; Freund and Buzsá ki, 1996; Kawaguchi and Kondo, 2002; Kawaguchi and Kubota, 1998; Klausberger and Somogyi, 2008; Markram et al., 2004; Monyer and Markram, 2004; Mott and Dingledine, 2003; Somogyi and Klausberger, 2005; Somogyi et…”
Interneuron dysfunction in psychiatric disorders (2012, background): “Pyramidal cells specialize in transmitting information between different cortical areas and from cortical areas to other regions of the brain, whereas interneurons primarily contribute to local neural assemblies, where they provide inhibitory inputs and shape synchronized oscillation”
Morpho-physiological Criteria Divide Dentatecc Gyrus Interneurons into Classes (2013, background): “6B): FS non-AC BCs with axon collaterals primarily located in the granule cell layer (orange); AC and moderately slow spiking HICAP cells with axon largely confined to the inner molecular layer (yellow); AC TML cells with axonal distribution in the total molecular layer (blue), FS HIPP-like neurons ”
Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning (2015, methodology): “…analysis of the roles of histologically identified interneurons in SPW-Rs was performed in an elegant series of studies by Somogyi, Klausberger et al., using juxtacellular recordings in urethane-ketamine anesthetized rats (Klausberger et al., 2003, 2004, 2005; cf. Klausberger and Somogyi, 2008).”
Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics (2017, positive): “In hippocampal area CA1 – one of the architecturally simplest cortical structures – GABAergic neurons have been divided so far into at least 23 classes of distinct connectivity, firing patterns, and molecular content (Bezaire and Soltesz, 2013; Freund and Buzsaki, 1996; Klausberger and Somogy”
Quantitative Assessment of CA1 Local Circuits: Knowledge Base for Interneuron-Pyramidal Cell Connectivity (2013, methodology): “PPA cells are found at the border of strata radiatum and lacunosum-moleculare (Somogyi and Klausberger, 2005; Klausberger and Somogyi, 2008).”
Plasticity during Sleep Is Linked to Specific Regulation of Cortical Circuit Activity (2017, background): “…of PV+ neurons basket cells are most frequent in the neocortex but, chandelier cells also occur in considerable numbers with projections typically targeting many more pyramidal cells than those of the basket cells which is likely associated with different functions (Klausberger and Somogyi, 2008).”