Receptive field formation by interacting excitatory and inhibitory synaptic plasticity
By Claudia Clopath, Tim P. Vogels, Robert Froemke, Henning Sprekeler. 2016
37 citations recorded by the source corpus.
The stimulus selectivity of synaptic currents in cortical neurons often shows a co-tuning of excitation and inhibition, but the mechanisms that underlie the emergence and plasticity of this co-tuning are not fully understood. Using a computational model, we show that an interaction of excitatory and inhibitory synaptic plasticity reproduces both the developmental and – when combined with a disinhibitory gate – the adult plasticity of excitatory and inhibitory receptive fields in auditory cortex. The co-tuning arises from inhibitory plasticity that balances excitation and inhibition, while excitatory stimulus selectivity can result from two different mechanisms. Inhibitory inputs with a broad stimulus tuning introduce a sliding threshold as in Bienenstock-Cooper-Munro rules, introducing an excitatory stimulus selectivity at the cost of a broader inhibitory receptive field. Alternatively, input asymmetries can be amplified by synaptic competition. The latter leaves any receptive field plasticity transient, a prediction we verify in recordings in auditory cortex.
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- Friedemann Zenke
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- Rahaf Aljundi
- Yoshua Bengio
- Fei Ye
- Vincenzo Lomonaco
- Arslan Chaudhry
Citations in the corpus
- The temporal paradox of Hebbian learning and homeostatic plasticity (2017, positive): “It has been suggested, for instance, that ISP in conjunction with a fixed plasticity threshold at the excitatory synapse could have a similar effect as the sliding threshold in the BCM model [79].”