Morpho-physiological Criteria Divide Dentatecc Gyrus Interneurons into Classes

By J. Hosp, Michael Strüber, Y. Yanagawa, K. Obata, Imre Vida, Peter Jonas, M. Bartos. 2013

115 citations recorded by the source corpus.

GABAergic inhibitory interneurons control fundamental aspects of neuronal network function. Their functional roles are assumed to be defined by the identity of their input synapses, the architecture of their dendritic tree, the passive and active membrane properties and finally the nature of their postsynaptic targets. Indeed, interneurons display a high degree of morphological and physiological heterogeneity. However, whether their morphological and physiological characteristics are correlated and whether interneuron diversity can be described by a continuum of GABAergic cell types or by distinct classes has remained unclear. Here we perform a detailed morphological and physiological characterization of GABAergic cells in the dentate gyrus, the input region of the hippocampus. To achieve an unbiased and efficient sampling and classification we used knock‐in mice expressing the enhanced green fluorescent protein (eGFP) in glutamate decarboxylase 67 (GAD67)‐positive neurons and performed cluster analysis. We identified five interneuron classes, each of them characterized by a distinct set of anatomical and physiological parameters. Cross‐correlation analysis further revealed a direct relation between morphological and physiological properties indicating that dentate gyrus interneurons fall into functionally distinct classes which may differentially control neuronal network activity. © 2013 The Authors. Hippocampus Published by Wiley Periodicals, Inc.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

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Citations in the corpus

Re-evaluating circuit mechanisms underlying pattern separation (2019, positive): “The diversity of dentate interneurons is also likely to enable them to closely match excitation and spike threshold and confer precise control over granule cell firing (Halasy and Somogyi, 1993; Sik et al., 2006; Hosp et al., 2014).”
Extended interneuronal network of the dentate gyrus (2017, background): “…system, since the local (i.e., withinDG) interneuronal subtypes supplying inhibition to the DG granule cells (GCs) are relatively well described and are known to play key roles in the regulation of informational flow from the entorhinal cortex to the downstream CA regions (Hosp et al., 2014).”
Physiological properties and behavioral correlates of hippocampal granule cells and mossy cells (2017, unknown): “The excitatory actions of granule cells and mossy cells are balanced by a diverse population of interneurons (Amaral, 1978; Halasy and Somogyi, 1993; Sik et al., 1997; Acsády et al., 1998; Hosp et al., 2014).”