Meta‐analysis of the association between a serotonin transporter promoter polymorphism (5‐HTTLPR) and anxiety‐related personality traits

By Srijan Sen, Margit Burmeister, D. Ghosh. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2004

787 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Clinical Psychology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6ab783e05d9425d1a9e3ff22edf03e1d0b8ce344

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Citations in the corpus

A susceptibility gene for affective disorders and the response of the human amygdala. (2005, neutral): “Moreover, 2 recent metaanalyses have indicated that the behavioral instrument used in our study (ie, Tridimensional Personality Questionnaire-HA) is not sensitive to the 5-HTTLPR, even in much larger samples, and that the neuroticism scale based on the 5-factor model of personality is more strongly ”
Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. (2008, background): “(2007): Midbrain serotonin transporter binding potential measured with [(11)C]DASB is affected by serotonin transporter genotype.”
The genetics of addictions: uncovering the genes (2005, methodology): “106 standard deviation increment in anxiety that was measured on personality scale”
Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies. (2008, background): “The short allele has been most widely studied in relation to the risk of developing anxiety and mood disorders, possibly mediated by the personality trait of neuroticism (Caspi et al., 2003; Lesch et al., 1996; Sen et al., 2004).”
Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. (2006, background): “106 SD in dimensional anxiety.(31) Gene-environment interaction is among the confounding factors.”
Genetics of the Human Personality (2010, background): “Sen et al. (2004b) suggested a weak gene-gene interaction in NEO-PI neuroticism in 384 subjects.”
5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression (2005, background): “Specifically, the 5-HTTLPR short allele ( s ) has reduced transcriptional efficiency compared with the long allele ( l ), and individuals carrying the s allele tend to have increased anxiety related temperamental trait”
Culture–gene coevolution of individualism–collectivism and the serotonin transporter gene (2009, background): “…that the S allele of the serotonin transporter gene (5-HTTLPR) is associated with increased negative emotion, including heightened anxiety (Sen et al. 2004; Munafò et al. 2005), harm avoidance (Munafò et al. 2005), fear conditioning (Lonsdorf et al. 2009), attentional bias to negative…”
Functional polymorphism (5-HTTLPR) in the serotonin transporter gene is associated with subjective well-being: evidence from a US nationally representative sample (2011, background): “12 and subsequent studies report that about 10p of variance in anxiety-related traits is contingent upon serotonin transporters”