Herpes Simplex Virus Encephalitis in Human UNC-93B Deficiency

By A. Casrouge, Shen-Ying Zhang, Celine Eidenschenk, E. Jouanguy, A. Puel, Kun Yang, A. Alcais, C. Picard, Nora Mahfoufi, Nathalie Nicolas and 18 more. Science, 2006

743 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6a5f5c425762065d7f37f5843b458e4c19c676d6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Taro Kawai
2. O. Takeuchi
3. E. Wherry
4. T. Mogensen
5. A. García‐Sastre
6. Rafi Ahmed
7. Charles M. Rice
8. Subhra K. Biswas

In Immunology

1. Shizuo Akira
2. Taro Kawai
3. T. Mogensen
4. O. Takeuchi
5. Rafi Ahmed
6. E. Wherry
7. R. Ransohoff
8. Herbert W. Virgin

In Molecular Biology

1. Taro Kawai
2. Shizuo Akira
3. O. Takeuchi
4. T. Mogensen
5. Rafi Ahmed
6. Charles M. Rice
7. Subhra K. Biswas
8. T. Maniatis

Citations in the corpus

• Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 (2020, background): “We found that 24 variants of eight genes were deleterious (including all the pLOF variants) because they were loss-of-expression, LOF, or severely hypomorphic: TLR3 (N = 4 variants), UNC93B1 (N = 1), TICAM1 (N = 3), TBK1 (N = 2), IRF3 (N = 2), IRF7 (N = 8), IFNAR1 (N = 3), and IFNAR2 (N = 1) (table ”
• Innate Immunity to Virus Infection (2009, background): “In addition, an autosomal recessive mutation in UNC93B in humans results in impaired immune responses against herpes simplex virus-1 (HSV-1) encephalitis (85).”
• Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, neutral): “Finally, a genetic predisposition to HSV encephalitis was identified in two children lacking functional UNC-93B (52), an ER protein required for delivering nucleotide-sensing TLRs (TLR3, -7, -8, and -9) from the ER to endosomes (190, 351).”
• Redefining chronic viral infection. (2009, positive): “virus infection, selectively predispose the host to herpes simplex encephalitis (Casrouge et al., 2006; Zhang et al., 2007).”
• The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors (2010, background): “It is reported that UNC93B1 deficiency is responsible for HSV-1 encephalitis in human patient”
• Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors (2010, positive): “Patients unresponsive to TLR3, TLR7, TLR8, and TLR9 (UNC-93B deficiency) share the narrow viral phenotype of TLR3-deficient patients, with herpes simplex encephalitis (Casrouge et al., 2006; Zhang et al., 2007).”
• Interferons at age 50: past, current and future impact on biomedicine (2007, background): “Conversely, patients with defects in the production of type I IFNs, due to mutation of the UNC93B gene, are highly susceptible to herpes simplex virus 1 (HSv1) encephalitis 24 .”