p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage.

By H. Reinhardt, Aaron Aslanian, J. Lees, Michael B. Yaffe. Cancer Cell, 2007

619 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/6a3bc856382cba72d62d4232d8419229b3b8d463

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In Cell Biology

1. Kenneth S. Kosik
2. L. Zou
3. E. Wagner
4. A. Nebreda

In Molecular Biology

1. A. Nebreda
2. J. Harper
3. Kenneth S. Kosik
4. L. Zou
5. E. Wagner
6. Alexandre Maréchal
7. T. Papagiannakopoulos
8. Stephen P. Jackson

In Oncology

1. J. Harper
2. L. Zou
3. E. Wagner
4. A. Nebreda
5. Alexandre Maréchal
6. D. Hanahan
7. R. Weinberg
8. Stephen J. Elledge

Citations in the corpus

• Signal integration by JNK and p38 MAPK pathways in cancer development (2009, background): “The p38α inhibitors may also be useful to treat tumours that rely on p38 MAPK activity for progression, or could be combined with DNA-damaging chemotherapy to trigger cancer cell death by impairing p38α-mediated cell cycle arrest and DNA repair mechanism”
• The DNA damage response: ten years after. (2007, background): “…of other kinases in the DDR, including Chk1, Chk2, the newly implicated MK2 kinase olecular Cell 28, December 14, 2007 ª2007 Elsevier Inc. 741 (Reinhardt et al., 2007), and casein kinases, which are known to be involved in this response, and to begin to decipher the significance that these…”
• MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. (2008, methodology): “To test this hypothesis, we compared apoptosis induction by addition of different doses of doxorubicin (adriamycin), a chemotherapeutic drug widely used to activate p53-mediated apoptosis by DNA damage in the presence or absence of miR-21 overexpression ( 39 ).”
• DNA damage sensing by the ATM and ATR kinases. (2013, background): “…et al. 1998; Liu et al. DNA breaks DNA repair DNA replication Transcription Cell-cycle arrest Apoptosis Senescence Sensors Transducers Effectors ATM and ATR Stalled/stressed DNA replication forks 2 Cite this article as Cold Spring Harb Perspect Biol 2013;5:a012716 2000; Reinhardt et al. 2007).”
• CDC25 phosphatases in cancer cells: key players? Good targets? (2007, background): “p38 and its downstream target, mitogen-activated protein kinase-activated protein kinase 2 ( MAPKAPK2 ) were initially shown to phosphorylate CDC25B and CDC25C in vitro and in vivo after UV-induced DNA damage, or induce CDC25A degradation after cisplatin treatmen”