CDC25 phosphatases in cancer cells: key players? Good targets?

By R. Boutros, V. Lobjois, B. Ducommun. Nature Reviews. Cancer, 2007

717 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/819b4d75bb37f1fc70e1ff6e27825fdc654b2edc

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In Cell Biology

1. M. Pagano
2. Marcos Malumbres

In Molecular Biology

1. David Frescas
2. M. Pagano
3. Marcos Malumbres

Citations in the corpus

• Strategies to improve radiotherapy with targeted drugs (2011, background): “Inhibition of ATM and downstream proteins, such as the cell division cycle 25 (CDC25) phosphatases, also targets cell cycle checkpoints in response to ionizing radiation that would otherwise prevent the propagation of DNA damag”
• Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer (2008, background): “High levels of Cdc25 have been found in many different human cancer”
• Cyclin-dependent kinases (2014, background): “Elimination of these phosphates by phosphatases of the Cdc25 family is then required for activation of CDKs and cell-cycle progression [3,23].”