Complex phenotype of mice lacking occludin, a component of tight junction strands.

By M. Saitou, M. Furuse, H. Sasaki, J. Schulzke, M. Fromm, H. Takano, T. Noda, S. Tsukita. Molecular Biology of the Cell, 2000

1,231 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/6a203a3fb5c6872aa6e71debe2add026cc5dbec7

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In Cancer Research

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4. L. Sorokin
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In Molecular Biology

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In Neurology

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Citations in the corpus

• Epithelial barriers in homeostasis and disease. (2010, background): “However, occludin knockout embryonic stem cells can differentiate into polarized epithelial cells with functional tight junctions (29), and although occludin knockout mice have severe disease with a complex phenotype (30), they do not appear to have defects in intestinal transport or barrier functio”
• Endothelial cell–cell junctions: happy together (2004, background): “By contrast, in the absence of certain TJ proteins, such as occludi”
• Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation (2012, neutral): “However, well-developed TJ strands were reported in cells lacking occludin (human or guinea pig testis) [34] and between adjacent occludin-deficient epithelial cells [34,35]; together with the report that occludin deficientmice are viable, exhibiting normal TJs morphology as well as intestinal epith”
• Multifunctional strands in tight junctions (2001, background): “These mice were born seemingly normal, but as they grew up, they began to show complex phenotypes, including marked growth retardation, chronic inflammation and HYPERPLASIA of the gastric epithelium, and mineral deposition in the brai”
• Reactive Oxygen Species in Inflammation and Tissue Injury (2014, neutral): “The composition of TJs and IEJs and their regulation by oxidative stress and permeability-enhancing agents is described next:”
• Tight junctions and cell polarity. (2006, background): “However, studies of occludin knockout mice show that the morphology of tight junctions is not affected and the barrier function of intestinal epithelium appears normal, although there are histological abnormalities in gastric epithelium (Saitou et al. 2000).”
• Tight junctions and the modulation of barrier function in disease (2008, background): “epithelium, calciWcation in the brain, testicular atrophy, the loss of cytoplasmic granules in striated duct cells of the salivary gland as well as the thinning of the compact bone, pointing to complex functions of the occludin protein (Saitou et al. 2000).”
• Intestinal mucosal barrier function in health and disease (2009, background): “This is particularly important as, despite numerous in vitro studies demonstrating a role for occludin in tight junction function, intestinal barrier function is intact in occludin-deficient mic”