Tight junctions and the modulation of barrier function in disease

By Carola Förster. Histochemistry and Cell Biology, 2008

607 citations recorded by the source corpus.

Tight junctions create a paracellular barrier in epithelial and endothelial cells protecting them from the external environment. Two different classes of integral membrane proteins constitute the tight junction strands in epithelial cells and endothelial cells, occludin and members of the claudin protein family. In addition, cytoplasmic scaffolding molecules associated with these junctions regulate diverse physiological processes like proliferation, cell polarity and regulated diffusion. In many diseases, disruption of this regulated barrier occurs. This review will briefly describe the molecular composition of the tight junctions and then present evidence of the link between tight junction dysfunction and disease.

Subfields: Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/edee5c09dd7fdbf788efef712f322c0bede63bb3

How researchers see this paper

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In Molecular Biology

1. N. Abbott
2. D. Begley

In Neurology

1. N. Abbott
2. Siti R. Yusof
3. D. Dolman
4. D. Begley
5. A. Patabendige
6. I. Galea
7. A. Varatharaj

Citations in the corpus

• Structure and function of the blood-brain barrier. (2010, background): “The barrier dysfunction can range from mild and transient tight junction opening to chronic barrier breakdown (Förster, 2008), and changes in transport systems and enzymes can also occur.”
• The blood-brain barrier in Alzheimer's disease (2017, unknown): “Claudins form the backbone of TJ strands, whereas occludin is incorporated into claudin-based strands and appears to regulate permeability (Förster, 2008).”