Identification of a novel FGF, FGF-21, preferentially expressed in the liver.

By Tetsuya Nishimura, Yuhki Nakatake, M. Konishi, N. Itoh. Biochimica et Biophysica Acta, 2000

843 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/69a0c9f5ae75285cde115387f38f88f2ea66fd88

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Citations in the corpus

Mitochondria: In Sickness and in Health (2012, background): “In adipose tissue, mitochondria-derived starvation responses trigger lipolysis to provide peripheral tissues with fuels (Kharitonenkov et al., 2005; Nishimura et al., 2000).”
Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis Through Adipose Tissue Crosstalk (2016, background): “Originally cloned by Nobuyuki Itoh’s group (Nishimura et al., 2000) and later identified in 2005 at Lilly Pharmaceuticals as a novel regulator of energy metabolism (Kharitonenkov et al., 2005), it has since been studied as a potential treatment for TDM and related metabolic disease.”
Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans (2008, background): “The FGF21 gene was originally reported to be predominantly expressed in the liver (13).”
Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice (2009, background): “FGF21 was isolated from a mouse embryo cDNA library and appeared as an atypical FGF preferentially expressed in tissues related with metabolic functions, such as liver (7) and pancreas (J.”
FGF-21 as a novel metabolic regulator. (2005, background): “FGF-21 (21) is a novel member of FGF family.”
Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. (2000, background): “However, otherand Moscatelli, 1992; Galzie et al., 1997; Naski and Orstudies report that hexasaccharides are biologically ac-nitz, 1998; Nishimura et al., 2000).”
Fibroblast growth factor 21 corrects obesity in mice. (2008, background): “B ON THE data obtained in a variety of animal models, fibroblast growth factor 21 (FGF21) (1) has recently emerged as an effective metabolic regulator of glucose and lipid homeostasis in the context of insulin resistance, glucose intolerance, and dyslipidemia (2–5).”
Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease (2010, background): “FGF21 is highly homologous between rodents and humans (1).”