As we wait: coping with an imperfect nomenclature for extracellular vesicles

By S. Gould, G. Raposo. Journal of Extracellular Vesicles, 2013

859 citations recorded by the source corpus.

There is increasing evidence that secreted vesicles play important roles in numerous aspects of biology (e.g. intercellular vesicle traffic, immunity, development, neurobiology and microbiology), contribute to many human diseases (e.g. cancer, neurodegenerative disorders and HIV/AIDS) and have significant biotechnological potential. This expanding interest in extracellular vesicles has also highlighted some vexing problems related to their nomenclature. At the first meeting of the International Society for Extracellular Vesicles (ISEV) in Gothenburg, Sweden (April 2012), the authors chaired a session on the issue of vesicle nomenclature. (Published: 15 February 2013) Citation: Journal of Extracellular Vesicles 2013, 2 : 20389 - http://dx.doi.org/10.3402/jev.v2i0.20389

Subfields: Cancer Research, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/694dcca48727aff1a323d3b41a969741fdb412da

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Citations in the corpus

Tumor-derived exosomes and their role in cancer progression (2016, background): “In addition to size, EVs also differ from one another by cellular mechanisms used for their secretion, molecular content and functional properties [3, 4].”
Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes (2013, background): “Different EVs were isolated to determine their respective RNA profiles.”
Biological properties of extracellular vesicles and their physiological functions (2015, background): “At present, at least 3main subgroups ofEVs havebeen defined (24): (a) apoptotic bodies, (b) cellular microparticles/microvesicles/ ectosomes and (c) exosomes (Fig.”
The biology and function of exosomes in cancer. (2016, background): “Similar size vesicles may also arise from diverse types of intraluminal vesicles (ILVs); however, specific markers to distinguish these vesicles are lacking; therefore, the generic term of EVs is currently being employed (4).”
Biogenesis and secretion of exosomes. (2014, neutral): “Raposo [80], given the lack of perfect demonstration of EVs’ endosomal origin, we can only suggest that researchers clearly specify their interpretation of whatever term they use for the EVs they analyse.”
Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles (2014, neutral): “The actual meaning of this word, however, is not universally accepted [see letter by Gould and Raposo (9)].”
EVpedia: a community web portal for extracellular vesicles research (2015, background): “2): (i) a database of publications and principal investigators, (ii) a database of vesicular proteins, mRNAs, miRNAs, lipids and Extracellular Vesicles: Diverse Nomenclature Prokaryotes Archaea Membrane Vesicles Gram-negative Bacteria Extracellular Vesicles, Membrane Blebs, Outer Membrane Blebs, Out”
Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression (2018, background): “Lack of guidelines regarding nomenclature of EVs has, however, resulted in an eclectic mix of names being published, for what are in essence overlapping populations (49).”
Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake (2016, neutral): “(Gould and Raposo 2013; Witwer et al. 2013); however, basic requirements of criteria for EVs have been established (Lötvall et al.”
Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes (2016, neutral): “However, the term exosome is often used in the literature for EVs of small size, passing through 220-nm pore filters or recovered by high-speed ultracentrifugation (8), in the absence of demonstration of their intracellular origin.”
Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper (2017, background): “the heterogeneous nature of vesicles present in the extracellular environment.[10] The typically presented classification divided EVs into two subtypes: EVs with”
Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper (2015, background): “Although the origin of exosomes and microvesicles has been defined precisely, current technology does not allow the experimental separation or even discrimination of different EV types of similar sizes (8).”