Biogenesis and secretion of exosomes.

By J. Kowal, M. Tkach, C. Théry. Current Opinion in Cell Biology, 2014

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Engineering exosomes for targeted drug delivery (2021, background): “Adapted with permission from [24], copyright 2014 Elsevier.”
Tumor-derived exosomes and their role in cancer progression (2016, background): “exosomes carry components of the endosomal sorting complex required for transport (ESCRT) and various ESCRT-associated molecules [15, 16].”
Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes (2016, background): “Internal vesicles generated within multivesicular endosomal compartments (MVB) are secreted when these compartments fuse with the PM, thus releasing their internal vesicles in the extracellular milieu: these EVs are termed exosomes (3, 7).”
A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option? (2020, background): “(MVBs) liberating intraluminal vesicles upon fusion with the plasma membrane [2].”
The biology and function of exosomes in cancer. (2016, background): “The proteome of exosomes includes endosomal, plasma, cytosolic, and nuclear proteins (23).”
Exosomes in cancer development, metastasis, and immunity (2019, background): “Nearly all mammalian cells secrete and take up exosomes [35, 36].”