B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.

By B. Salomon, D. Lenschow, L. Rhee, N. Ashourian, Bhagarith Singh, Arlene H. Sharpe, J. Bluestone. Immunity, 2000

2,325 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/691328e277cfe9c37927b7e4831ee795fe68fe70

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Citations in the corpus

IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells 1 (2004, background): “CD4 CD25 TReg protect lymphopenic mice from inflammatory bowel disease (IBD), autoimmune gastritis (15), wasting disease (4), and diabetes (16), and prevent transplant rejection (17) and immune response to tumors (18, 19).”
Foxp3 instability leads to the generation of pathogenic memory T cells in vivo (2009, neutral): “The paradigm in immunology is that autoimmunity is precipitated by an imbalance of pathogenic T cells and Foxp3 + regulatory T cells25,26.”
CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness (2002, background): “... transfer of disease mediated by autoreactive T cell clones, as well as disease induced by CD4 � T cell populations that are depleted of regulatory T cells (e.g., CD4 � CD25 � or the CD4 � CD45RB high subsets; references 5 and 6). Furthermore, a partial deficiency of CD4 � CD25 � T cells may also”
Control of regulatory T cell lineage commitment and maintenance (2009, background): “In addition to TCR signals, CD28 costimulatory signals have an essential cell-intrinsic role in the differentiation of tTreg cells as illustrated by marked decreases in frequencies of tTreg cells in CD28-deficient and CD80-CD86-deficient mice (Salomon et al., 2000; Tai et al., 2005).”
Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood (2001, background): “Such cells arise from the thymus (3), express CD4, CD25 (17), and intracellular CTLA-4 (9, 16), and their activation via the B7-CD28 pathway is essential for their induction and survival in the periphery (18).”
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. (2008, methodology): “T1D in the NOD-mouse model (Chen et al., 2005; Salomon et al., 2000 ).”
CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses1 (2002, background): “As recent studies have shown that immunoregulatory CD25 CD4 T cells express CTLA-4 (19, 23, 35), we wished to investigate its expression in our system.”