Oncomirs — microRNAs with a role in cancer

By A. Esquela-Kerscher, Frank J. Slack. Nature Reviews. Cancer, 2006

7,285 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c3965d029b5d0f3219bb98275d992a78ecdafee1

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Citations in the corpus

Genomic profiling of microRNA and mRNA reveals deregulated microRNA expression in prostate cancer (2008, background): “Up-regulation of microRNAs in tumors is common (5, 6, 8), and it is consistent with the known oncogenic activity of many microRNAs (22–25).”
An Analysis of Human MicroRNA and Disease Associations (2008, background): “There is increasing evidence suggesting that miRNAs play critical roles in many key biological processes, such as cell growth, tissue differentiation, cell proliferation, embryonic development, and apoptosis[6].”
MYB function in normal and cancer cells (2008, background): “Recently, there has been an almost explosive growth in our knowledge of the activities of microRNAs (miRNAs) in cancer and haematopoiesi”
Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy (2010, background): “It is thought that miRNAs contribute to tumorigenesis by negatively regulating the expression of their target”
MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. (2010, background): “OncomiRs that are upregulated in tumors function in tumor development mainly via repressing the expression of tumor suppressor or tumor suppressor–like genes (12, 13).”
Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues. (2008, background): “MicroRNA represents an important new class of regulatory biomolecules, with roles in processes as diverse as early development, cell proliferation and differentiation, apoptosis, fat metabolism, and oncogenesis (for reviews, see Ambros 2004; Bartel 2004; Esquela-Kerscher and Slack 2006; Calin and Cr”
Small non-coding RNAs in animal development (2008, background): “These recent advances place miRNAs and piRNAs firmly on the map of key developmental genes and point to their involvement in human diseases such as birth defects and cancer (reviewed in Ref”