Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins

By Minsoo Kim, C. Carman, T. Springer. Science, 2003

855 citations recorded by the source corpus.

Subfields: Immunology and Allergy, Molecular Biology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/686484975c6a401ffde2a0c5186a6b3fa9a6a840

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology and Allergy

1. Iain D. Campbell
2. M. Humphries
3. S. Shattil
4. C. Carman
5. B. Luo
6. S. Nourshargh
7. T. Springer
8. M. Ginsberg

In Molecular Biology

1. M. Humphries
2. Iain D. Campbell
3. C. Carman
4. B. Luo
5. S. Nourshargh
6. S. Shattil
7. T. Springer
8. J. Parsons

In Radiology, Nuclear Medicine and Imaging

1. Iain D. Campbell
2. M. Humphries

Citations in the corpus

• An Essential Role for Talin during αMβ2-mediated Phagocytosis (2007, background): “Interaction of talin head with the cytoplasmic domain of 2 is sufficient to increase binding of C3bi-RBCs in macrophages and transfected COS-7 cells (Figures 7 and 9). Moreover, talin and talin head interact with M2, as shown by coimmunoprecipitation and GST pull-down assays (Figures 3 and 4). This ”
• Structural basis of integrin regulation and signaling. (2007, background): “Furthermore, extracellular addition of Mn2+ and soluble ICAM-1, which induces integrin extension as shown by exposure of the KIM127 epitope, also induces α and β subunit cytoplasmic domain separation (35).”
• Integrin structure, activation, and interactions. (2011, methodology): “Evidence for this includes experiments using EM (Adair and Yeager 2002), disulfide cross-linking (Luo et al. 2004), activating mutations (Partridge et al. 2005), and FRET 4 Cite this article as Cold Spring Harb Perspect Biol 2011;3:a004994 of labeled cytoplasmic tails (Kim et al. 2003).”
• Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics (2004, background): “, and transmission of activation signals across the membrane involves separation between the α and β transmembrane and cytoplasmic domain”
• Structural Dynamics of α-Actinin-Vinculin Interactions (2005, background): “, the conserved proline residue in the B helix of R4), the spectrin repeats of -actinin are predicted to form similar unfolded intermediates in response to sheer stress, and -actinin binds to cadherin and integrin receptors in adherens junctions and focal adhesions, respectively, where mechanical st”
• Adhesion of membranes via receptor-ligand complexes: Domain formation, binding cooperativity, and active processes (2009, background): “In one of their conformations, the integrin molecules are extended and can bind to apposing ligands [102, 103, 104].”
• Getting to the site of inflammation: the leukocyte adhesion cascade updated (2007, background): “The most detailed information about integrin structural rearrangement during affinity upregulation in leukocytes comes from studies of LFA1 (Ref”
• Activation, coactivation, and costimulation of resting human natural killer cells (2006, background): “In the resting state, the aL and b2 cytoplasmic domains are close to each other and the extracellular domain is closed, but either inside-out signaling or ligand binding induces an extended conformation of the extracellular domain coupled to a spatial separation of the cytoplasmic domains (114).”
• Intracellular signalling controlling integrin activation in lymphocytes (2005, background): “FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) studies have shown that separation of the cytoplasmic regions of the α L - and β 2 -chain of LFA1 occurs following either inside-out signalling or ligand bindin”
• FAK phosphorylation sites mapped by mass spectrometry (2005, background): “Binding of the integrin cytoplasmic tails to the FERM domain of talin induces conformational changes in the integrin extracellular domains, thus increasing their affinity for ligands (Calderwood et al., 2004; Tadokoro et al., 2003; Calderwood et al., 2002; Kim et al., 2003 ).”