Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

By T. Xiao, J. Takagi, B. Coller, Jia-huai Wang, T. Springer. Nature, 2004

889 citations recorded by the source corpus.

Subfields: Hematology, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/de6dcba6b89723270e279b6ebd5f063ef7d32c56

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. M. Humphries
2. Iain D. Campbell

In Immunology and Allergy

1. Iain D. Campbell
2. A. Mould
3. Cheng-Long Zhu
4. Andrés J. García
5. F. Kong
6. M. Humphries
7. K. Legate
8. R. Fässler

In Molecular Biology

1. A. Mould
2. Cheng-Long Zhu
3. F. Kong
4. M. Humphries
5. Iain D. Campbell
6. Andrés J. García
7. K. Legate
8. R. Fässler

Citations in the corpus

• A bio-mechanical model for coupling cell contractility with focal adhesion formation (2008, background): “Recent studies (Xiao et al., 2004) have elucidated that integrins exist in two conformational states: (i) a low affinity (or bent) state and (ii) an active or ‘‘straight’’ state with a high affinity to the appropriate ligand (see Fig.”
• The integrins (2007, positive): “Binding of RGD-containing peptides or related compounds to a site in the headpiece of the integrin heterodimers has been shown in crystal structures of αVβ3 [4,5] and αIIbβ3 [6].”
• Genetic and cell biological analysis of integrin outside-in signaling. (2009, background): “Integrin activation is accomplished by large conformational changes in integrins, which has been proposed to include the swinging-out of the hybrid domain in the extracellular region to expose the ligand-binding site (Xiao et al. 2004; Luo et al. 2007).”
• Integrin structure, activation, and interactions. (2011, background): “Current knowledge of ectodomains has also been enhanced by structures of various integrin fragments including isolated a-I domains (Lee et al. 1995a) and b2-leg fragments (Beglova et al. 2002; Xiao et al. 2004; Shi et al. 2005).”
• INTEGRIN LIGANDS (2006, background): “Crystal structures of V3 and IIb3 complexed with RGD ligands have revealed an identical atomic basis for this interaction (Xiong et al., 2002; Xiao et al., 2004 ).”
• Demonstration of catch bonds between an integrin and its ligand (2009, positive): “Similar to the Fc–GG-7 interaction and consistent 1279DEMONSTRATION OF INTEGRIN–LIGAND CATCH BONDS • Kong et al. et al., 2002; Xiao et al., 2004).”