Structural basis of integrin regulation and signaling.

By B. Luo, C. Carman, T. Springer. Annual Review of Immunology, 2007

1,733 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/ea4dde38a328f059c8f6d8c4e01ea18386376329

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Citations in the corpus

The neutrophil in vascular inflammation (2011, background): “G protein-coupled receptors on rolling neutrophils bind chemokines sequestered on the apical endothelium, leading to 'inside-out' signals that induce conformational changes in β 2 integrins expressed by neutrophils that increase their avidity and affinity, thus resulting in neutrophil arrest 4 and s”
Controlling NK Cell Responses: Integration of Signals for Activation and Inhibition (2013, background): “In primary T cells, the β2 integrin LFA-1 remains in a closed conformation unless the TCR or a chemokine receptor transmits inside-out signals that trigger an extended conformation (116).”
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci (2008, background): “ITGAM is also a receptor for the complement component C3 degradation product, iC3”
Integrin Structure and Function (2010, background): “In the “switchblade” model (Luo et al. 2007), only extended integrins are predicted to bind ligand.”
Demonstration of catch bonds between an integrin and its ligand (2009, neutral): “Integrins are often expressed on cells in an inactive, low affinity state with slow on rate and/or fast off rate for ligand binding, but they can be activated to high affinity states with fast on rates and/or slow off rates (Hynes, 2002; Luo et al., 2007).”
The integrins (2007, neutral): “In the ‘switchblade model’, dissociation of the α and β cytoplasmic and transmembrane regions leads to dislocation of an epidermal growth factor (EGF)-like repeat in the β stalk, which causes the head region to extend outwards in a switchblade-like movement [17].”
Integrin signalling at a glance (2009, background): “The specifics of extracellular ligand binding and the range of known integrin ligands are reviewed elsewhere (Humphries et al., 2006; Luo et al., 2007 ).”