From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy

By B. Altman, Zachary E. Stine, C. V. Dang. Nature Reviews. Cancer, 2016

1,349 citations recorded by the source corpus.

The resurgence of research into cancer metabolism has recently broadened interests beyond glucose and the Warburg effect to other nutrients, including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, and explore the recent potential applications of basic science discoveries in the clinical setting.

Subfields: Biochemistry, Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8c755b866ebdeeb57ddae21a9953b09a58461389

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Ping Gao
2. Huafeng Zhang
3. Linchong Sun

In Molecular Biology

1. Ping Gao
2. Huafeng Zhang
3. Linchong Sun

Citations in the corpus

• The Tumor Suppressor Protein p53 and the Ferroptosis Network (2018, neutral): “The first step of glutamine catabolism is its conversion to glutamate, which is catalyzed by cytosolic glutamine amidotransferases or by mitochondrial glutaminases [73].”
• Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation (2018, background): “Endogenous glutamine synthesis does not meet the human body’s demands in catabolic conditions, such as in cancer [25], sepsis [4,26], infections [27,28], surgeries [8], traumas [10], as well as during intense and prolonged physical exercise [29,30].”
• Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “Although glutamine is the most abundant amino acid in the culture medium and is essential for immune cell function and tumor development (Gao et al., 2009; Altman et al., 2016; Kelly and Pearce, 2020), Ishak Gabra et al.”
• TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019 (2019, background): “Glutaminolysis is a two-step reaction that involves the conversion of glutamine to glutamate by glutaminase (GLS) and then to α-ketoglutarate through glutamate dehydrogenase or aminotransferase enzymes [230].”