Enhancing Gene Targeting with Designed Zinc Finger Nucleases

By M. Bibikova, Kelly J. Beumer, J. Trautman, D. Carroll. Science, 2003

819 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/681e03a2e4c3585cbaec818086a3b20237bcfc05

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In Molecular Biology

Citations in the corpus

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins (2014, background): “2013), rapidly catching up with their precursors, namely, zinc finger nucleases (ZFNs) (Bibikova et al. 2003; Porteus and Baltimore 2003) and transcription activator-like effector nucleases (TALENs) (Miller et al.”
Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System (2013, background): “This enables precisely defined changes to be achieved by coinjection with a homologous template (Bibikova et al., 2003; Porteus and Baltimore, 2003).”
Gene targeting using zinc finger nucleases (2005, background): “This work and the work of Bibikova et al. (2003) has been briefly reviewed elsewhere 38 .”
Genetic manipulation of genes and cells in the nervous system of the fruit fly (2011, methodology): “Zinc finger nucleases have been used to generate mutations by nonhomologous end joining (Bibikova et al., 2002;Beumer et al., 2006) or homologous recombination with an ectopic template as a substrate (Bibikova et al., 2003; Beumer et al., 2006).”
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. (2013, background): “…to yield indels (Barnes, 2001) or by homologous recombination (HR) if homologous donor templates are available (van den Bosch et al., 2002), thereby enhancing the efficiency of HR-based gene targeting (Bibikova et al., 2003; Porteus and Carroll, 2005; Thomas and Capecchi, 1987; Urnov et al., 2005).”
Genome editing with engineered zinc finger nucleases (2010, methodology): “( Box 1 ), which was initially applied to Drosophila melanogaster”
Highly efficient endogenous human gene correction using designed zinc-finger nucleases (2005, background): “, demonstrated that the endonuclease I- Sce I can potentiate HR into loci previously engineered to contain its own recognition site, and the Carrol”
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases (2014, background): “Programmable nucleases, which include zinc finger nucleases (ZFNs) (Bibikova et al. 2003; Urnov et al. 2005; Kim et al. 2011), transcription activator-like effector (TALE) nucleases (TALENs) (Miller et al. 2011; Kim et al. 2013a), and RNA-guided endonucleases (RGENs) (Cho et al. 2013a; Cong et al.…”
Development and Applications of CRISPR-Cas9 for Genome Engineering (2014, positive): “A series of studies by Haber and Jasin (Rudin et al., 1989; Plessis et al., 1992; Rouet et al., 1994; Choulika et al., 1995; Bibikova et al., 2001; Bibikova et al., 2003) led to the realization that tar- geted DNA double-strand breaks (DSBs) could greatly stimulate genome editing through HR-mediated”
Reprogramming homing endonuclease specificity through computational design and directed evolution (2013, background): “Targeted gene correction requires site-speciﬁc DNA cleavage to initiate cellular programs for DNA break repair (1).”
TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain (2010, background): “Following binding at the preselected site, a DSB is produced by the action of the ZFN’s FokI cleavage domain (4).”
A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity (2011, background): “Accordingly, designer nuclease-based genome engineering has been successfully established in more than 10 model organisms thus far, including plants (3,4), invertebrates (5), fish (6,7) and mammals (8).”
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases (2008, methodology): “Assembled ZFPs were cloned in-frame as NH2-terminal fusions to the catalytic domain of Fok”