Cofilin Promotes Actin Polymerization and Defines the Direction of Cell Motility

By M. Ghosh, Xiaoyan Song, G. Mouneimne, M. Sidani, D. Lawrence, J. Condeelis. Science, 2004

694 citations recorded by the source corpus.

Subfields: Biomaterials, Biophysics, Cell Biology

View Paper: https://www.semanticscholar.org/paper/67f7d69a2ee02804e7c57486e563cf0f59f3e75d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biophysics

1. J. Pollard
2. J. Condeelis
3. Thomas D. Pollard
4. J. Wyckoff
5. E. Stanley
6. Elaine Lin
7. Yarong Wang
8. J. Segall

In Cell Biology

1. J. Pollard
2. T. Svitkina
3. Thomas D. Pollard
4. J. Condeelis
5. J. Wyckoff
6. E. Stanley
7. Elaine Lin
8. Yarong Wang

Citations in the corpus

• Molecular mechanisms of invadopodium formation (2005, positive): “Previous studies showed that cofilin stimulates lamellipod protrusion and cell migration (Chan et al., 2000; Dawe et al., 2003; Ghosh et al., 2004).”
• Rho GTPases: biochemistry and biology. (2005, background): “ADF/cofilin severs actin filaments, leading to an increase in uncapped barbed ends that serve as sites for actin polymerization and filament elongation (Ghosh et al. 2004).”
• The Actin Cytoskeleton and Actin-Based Motility (2018, background): “Actin filament severing by ADF/cofilin can also help the cell to start a new lamellipodium by creating new uncapped barbed ends (Ghosh et al. 2004).”
• Chemotaxis in cancer (2011, background): “Signalling through either a chemokine receptor (a GPCR) or a growth factor receptor (a receptor tyrosine kinase (RTK)) will result in the initial protrusion required to set the directional compass and to define the direction of cell migration during chemotaxi”
• The Growth Cone Cytoskeleton in Axon Outgrowth and Guidance (2011, background): “These activities promote filament assembly as cofilin reveals new polymerization-competent barbed ends, and increases the available pool of actin monomers (Chan et al. 2000; Ichetovkin et al. 2002; Ghosh et al. 2004).”
• Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin. (2006, background): “Severing by cofilin might create more ends for polymerization (Ichetovkin et al., 2002) as suggested to explain an increase of actin polymer in carcinoma cells after EGF stimulation or local release of microinjected caged cofilin (Ghosh et al., 2004; Zebda et al., 2000).”
• Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. (2007, result): “The ‘‘invasion signature’’ implicates signaling pathways involved in chemotaxis of carcinoma cells (37, 39, 40), consistent with the chemotactic behavior of tumor cells adjacent to macrophages observed in vivo in this study and previously in vitro (11).”