Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin.
By E. Andrianantoandro, Thomas D. Pollard. Molecules and Cells, 2006
693 citations recorded by the source corpus.
Subfields: Biophysics, Cell Biology, Ecology, Evolution, Behavior and Systematics
View Paper: https://www.semanticscholar.org/paper/629f1a41337bd34648868e385f1ed9436c697542
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Citations in the corpus
- Actin and Actin-Binding Proteins. (2016, background): “Therefore, steady state severing is optimal at concentrations of cofilin far below the Kd (Andrianantoandro and Pollard 2006).”
- Actin dynamics, architecture, and mechanics in cell motility. (2014, background): “Part of the confusion stems from the fact that in a bulk assay ADF/cofilin is reported to increase by 25-fold the rate of actin dissociation from pointed ends; however, evanescent wave microscopy (also known as TIRF microscopy) of single filaments in the presence of ADF/cofilin does not confirm this”
- Regulation of actin assembly associated with protrusion and adhesion in cell migration. (2008, background): “Based on real-time imaging of Oregon green actin filaments, it was recently proposed that, at low concentration, ADF promotes the depolymerization by severing actin filaments, not by increasing the dissociation between subunits, whereas it nucleates actin filaments at higher concentrations (6).”
- ADF/Cofilin: A Functional Node in Cell Biology (2010, background): “In vitro studies have demonstrated that if the ratio of cofilin/actin subunits in a filament is low (<1/100 of the KD), persistent filament severing results [5].”