Assessment of growth parameters and life span of GHR/BP gene-disrupted mice.

By K. Coschigano, David R. Clemmons, L. Bellush, J. J. Kopchick. Endocrinology, 2000

629 citations recorded by the source corpus.

Subfields: Cancer Research, Endocrinology, Diabetes and Metabolism, Physiology

View Paper: https://www.semanticscholar.org/paper/67c62cc02d670f3a066522291b97ca48e7616fc8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. N. Sharpless
2. J. Campisi
3. Julia Salzman

In Physiology

1. N. Sharpless
2. J. Speakman
3. J. Campisi
4. David Raubenheimer
5. Stephen J. Simpson
6. Mark P. Mattson
7. V. Longo

Citations in the corpus

• Overview of caloric restriction and ageing. (2005, background): “Furthermore, Coschigano et al. (2000) have studied mice in which the growth hormone receptor/binding protein gene has been disrupted, and found that they exhibit high levels of plasma growth hormone, very low levels of plasma IGF-1, and life extension.”
• Ink4a/Arf expression is a biomarker of aging. (2004, methodology): “We tested Ink4a/Arf expression in both lung and kidney from old and young growth hormone receptor+/+ (GHR+/+) and GHR–/– mice (37) that had been fed ad libitum or CR diets.”
• Body size, energy metabolism and lifespan (2005, background): “These effects appear to be homologous in both Drosophila and mice (Tatar, 1999; Coschigano et al., 2000; Flurkey et al., 2001, 2002; Bartke, 2001; Hsieh et al., 2002a,b; Tatar et al., 2003; Brown-Borg, 2003).”
• IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice (2003, background): “The recent targeted inactivation of the growth hormone receptor itself, which strongly decreases circulating IGF-I and impairs growth and development, also increases lifespa”
• Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. (2001, background): “The level of serum IGF1 in a similar Ghr knockout was reportedly 7–10% of normal (Zhou et al., 1997; Sjö gren et al., 2000; Coschigano et al., 2000) or undetectable (Chandrashekar et al., 1999).”
• Trends in oxidative aging theories. (2007, background): “There are only two interventions consistently reported to increase life span in laboratory mice: caloric restriction [165] and modulation of the anabolic GH/IGF-1 axis [64,65,166,167].”