Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

By Bahareh Ajami, Jami L. Bennett, C. Krieger, K. McNagny, F. Rossi. Nature Neuroscience, 2011

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Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis (2012, positive): “However, when analyzed, the contribution of these infiltrating cells was found to be transient (Ajami et al., 2011; Leuschner et al., 2012), whereas resident macrophages bring about the resolution of the inflammatory response and restore macrophage homeostasis (Davies et al.”
Developmental and Functional Heterogeneity of Monocytes. (2018, background): “pathogenic function of monocytes during disease development (Ajami et al., 2011; King et al., 2009; Mildner et al., 2009).”
Tissue-Resident Macrophage Ontogeny and Homeostasis. (2016, background): “In addition, monocytes recruited to inflamed tissues often fail to stably engraft once inflammation resolves (Ajami et al., 2007, 2011; Hashimoto et al., 2013; Zigmond et al., 2014).”
Progress in tumor-associated macrophage (TAM)-targeted therapeutics (2017, neutral): “The monocytes in blood circulation provide a reservoir of macrophages for mounting immune and inflammatory responses [17].”