Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype
By D. Starczynowski, F. Kuchenbauer, B. Argiropoulos, Sandy S. Sung, Ryan D. Morin, A. Muranyi, M. Hirst, D. Hogge, Marco A. Marra, R. Wells and 4 more. Nature Medicine, 2010
683 citations recorded by the source corpus.
Subfields: Cancer Research
View Paper: https://www.semanticscholar.org/paper/9de8e466a5ed4a7b6f975968e9bf958ea6ff10a5
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In Cancer Research
- David Baltimore
- D. Rao
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- Phillip A. Sharp
- Margaret S. Ebert
- Luke A. O'Neill
- Manel Esteller
- M. Boldin
Citations in the corpus
- MicroRNAs: the fine-tuners of Toll-like receptor signalling (2011, background): “Another Toll/IL-1R domain-containing adaptor protein, MYD88 adaptor-like protein (MAL; also known as TIRAP), which functions as a bridging adaptor for TLR2- and TLR4-mediated MYD88-dependent signalling, has emerged as a target of miR-145 (Ref”
- miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice (2011, background): “Moreover, chimeric mice overexpressing TRAF6 in the hematopoietic compartment were shown to develop either BM failure or AML starting at 5 mo after BM transplantation (Starczynowski et al., 2010).”
- MicroRNA sponges: progress and possibilities. (2010, background): “Eight weeks post-transplantation, the animals’ blood cells manifested most of the features of MDS. Observation over the long term proved the benefit of including a fluorescent reporter in the competition assay: Over the course of several months, YFP+ cells were depleted from the blood of the sponget”
- Non-coding RNAs in human disease (2011, background): “In addition, specific miRNA defects have been shown to underlie particular diseases; for example, miR-145 and miR-146a deletions are involved in the 5q syndrome phenotyp”
- microRNA regulation of inflammatory responses. (2012, methodology): “In contrast, repression of the miR-146a targets IRAK1 and TRAF6, both signaling proteins in the TLR/IL-1R pathways, reduces the magnitude of this reaction (39).”