Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation

By K. Eggan, H. Akutsu, J. Loring, L. Jackson‐Grusby, M. Klemm, W. Rideout, R. Yanagimachi, R. Jaenisch. Proceedings of the National Academy of Sciences of the United States of America, 2001

650 citations recorded by the source corpus.

Subfields: Molecular Biology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/67bae79b19d3045808f4b6307393a9bcc317b411

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. K. Hochedlinger
2. R. Jaenisch
3. M. Stadtfeld
4. G. Daley
5. A. Bird
6. S. Yamanaka
7. Yi Zhang
8. J. Hanna

In Public Health, Environmental and Occupational Health

1. R. Jaenisch
2. M. Stadtfeld
3. K. Hochedlinger

Citations in the corpus

• Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals (2003, background): “The efficiency of nuclear reprogramming depends on the differentiation state of the donor nucleus: the survival of clones derived from ES cell donor nuclei is 10–20 times higher than that of clones derived from somatic donor”
• Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. (2002, positive): “We previously showed that injection of wild-type F1 ES cells into tetraploid blastocysts resulted in viable mice from 4%–10% of the manipulated embryos ( Eggan et al., 2001 ) and that injection of ntES”
• Distinct factors control histone variant H3.3 localization at specific genomic regions (2010, background): “castaneus (Eggan et al., 2001; Mikkelsen et al., 2007), and was a gift from Rudolf Jaenisch.”
• Induced pluripotency: history, mechanisms, and applications. (2010, background): “In fact, ESCs are capable of producing entirely ESC-derived animals after injection into tetraploid blastocysts (Nagy et al. 1990; Eggan et al. 2001), which by themselves develop into extraembryonic tissues only but fail to give rise to the embryo proper, thereby passing the most stringent developme”
• Epigenetic memory in induced pluripotent stem cells (2010, methodology): “NP-iPSC and Bl-iPSC were compared to ntESC generated from neural progenitor cells (NP-ntESC 8 ), blood progenitor cells (B-ntESC 31 ), and fibroblasts (F-ntESC 31, 32 ), as well as fESC.”
• Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. (2008, methodology): “Correct clones were injected into tetraploid blastocysts to produce entirely ES cell-derived mice (Eggan et al., 2001).”
• Multiple knockout mouse models reveal lincRNAs are required for life and brain development (2013, neutral): “5 embryos from heterozygous intercrosses (Eggan et al., 2001).”
• Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development (2008, methodology): “After addition of MC1-TK for negative selection, the resulting targeting vectors were introduced by gene targeting (Nagy et al., 2003) into 129/Sv 3 C57BL/6J F1 hybrid ES cells (Eggan et al., 2001).”