Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state.

By M. Fulco, R. Schiltz, S. Iezzi, M. King, Po Zhao, Y. Kashiwaya, Eric P. Hoffman, R. Veech, V. Sartorelli. Molecules and Cells, 2003

625 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/67b03b65fe327111f983893e115adf1bb47d4127

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Geriatrics and Gerontology

1. L. Guarente
2. Johan Auwerx
3. D. Sinclair
4. E. Verdin
5. M. Haigis
6. C. Cantó
7. R. Houtkooper
8. Laura Bordone

In Molecular Biology

1. L. Guarente
2. W. Gu
3. E. Verdin
4. D. Sinclair
5. Johan Auwerx
6. Laura Bordone
7. M. Haigis
8. R. Mostoslavsky

In Physiology

1. Johan Auwerx
2. D. Sinclair
3. C. Cantó
4. E. Verdin
5. R. Houtkooper
6. L. Guarente
7. M. Haigis
8. R. Mostoslavsky

Citations in the corpus

• SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM (2012, background): “SIRT1 has been shown to retard muscle differentiation through its interaction with MyoD (111).”
• A "mitochondrial cascade hypothesis" for sporadic Alzheimer's disease. (2004, background): “Recent data suggest a single mediator, the cell redox state (which is reflected by ratios of particular oxidized and reduced substrate variants, such as NADþ and NADH), and by extension reactive oxygen species (ROS), regulates the balance between these diametric processes [27–30].”
• SIRT1 controls endothelial angiogenic functions during vascular growth. (2007, background): “…histones, SIRT1 interacts with several substrates, including transcription factors, which mediate specific functions of SIRT1 (Luo et al. 2001; Vaziri et al. 2001; Fulco et al. 2003; Takata and Ishikawa 2003; Brunet et al. 2004; Motta et al. 2004; Picard et al. 2004; Rodgers et al. 2005).”
• Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. (2006, background): “Pol I transcription is highly coordinated with cellular metabolism and cell proliferation (Grummt 1999).”
• Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. (2006, background): “Consistent with such wide-spread effects of RSV on fat and muscle was the previous work showing increased fat mobilization by genetically manipulating SIRT1 activity (Picard et al., 2004), as was the capacity of SIRT1 to modulate muscle-cell differentiation (Fulco et al., 2003).”
• FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. (2004, positive): “1College of Physicians & Surgeons of Columbia University New York, New York 10032 Sirt1-dependent deacetylation dampens p53 transcriptional effects, thus enabling cells to survive under condi-2 Ludwig Institute for Cancer Research University of California, San Diego tions that would otherwise cause ”
• Regulation of SIRT1 and Its Roles in Inflammation (2022, background): “Several studies have identified that in many pathophysiological processes, the NAD/NADH ratio is significantly correlated with SIRT1 activity (54).”