Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients

By Susan R. Schwab, J. P. Pereira, M. Matloubian, Ying Xu, Yong Huang, J. Cyster. Science, 2005

815 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/679f7f7c013f8c9dc6de8a3a3634033c9c18e1bf

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In Immunology

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Citations in the corpus

The outs and the ins of sphingosine-1-phosphate in immunity (2011, neutral): “Constitutive levels of S1P in most tissues are low, and this is probably due to the activity of S1P lyas”
Finding a way out: lymphocyte egress from lymphoid organs (2007, background): “The concentration of S1P in lymph, in the nanomolar range, is approximately one sixth the concentration in plasm”
THE ALLIANCE OF SPHINGOSINE-1-PHOSPHATE AND ITS RECEPTORS IN IMMUNITY (2008, background): “Notable exceptions are the blood, where S1P levels are in the low-micromolar range and are mainly contributed by erythrocytes, and the lymph, where S1P levels are in the hundred-nanomolar rang”
Follicular shuttling of marginal zone B cells facilitates antigen transport (2008, background): “S1P is abundant in blood and is thought to be present in much smaller amounts in the follicles and T zones of lymphoid tissue”
An overview of sphingolipid metabolism: from synthesis to breakdown (2010, background): “The relationship between symptoms associated with vitamin B6 deficiency, the dietary precursor to PLP, and alterations in sphingolipid metabolism are unclear, but will be important to assess since inhibition of SPT or S1P lyase could result in demyelination and altered immune function respectively [”
“Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets (2008, background): “5 to 75 pmol/mg (Edsall and Spiegel, 1999; Schwab et al., 2005).”
Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. (2007, background): “This egress step can be inhibited by the pharmacological blockade of S1P lyase with 2-acetyl-4-tetrahydroxybutylimidazole (THI) (Schwab et al., 2005).”