Regulation of the HIF-1alpha level is essential for hematopoietic stem cells.

By K. Takubo, N. Goda, Wakako Yamada, Hirono Iriuchishima, Eiji Ikeda, Y. Kubota, H. Shima, Richard J. Johnson, A. Hirao, M. Suematsu and 1 more. Cell Stem Cell, 2010

846 citations recorded by the source corpus.

Subfields: Cancer Research, Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/67622eb2d00919ada4d29b82ec5809f643f43808

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. G. Semenza
2. Richard J. Johnson
3. T. Suda
4. K. Takubo
5. C. V. Dang
6. M. C. Simon
7. D. Hanahan
8. Navdeep S. Chandel

In Hematology

1. G. Semenza
2. T. Suda
3. K. Takubo

In Immunology

1. G. Semenza
2. Richard J. Johnson
3. Anna Katharina Simon

Citations in the corpus

• Metabolic Plasticity in Stem Cell Homeostasis and Differentiation (2012, positive): “This is consistent with the observation that genetic deletion of HIF1 subunits results in defective hematopoiesis, vascularization, and neuralfold closure, resulting in embryonic lethality (Mohyeldin et al., 2010; Takubo et al., 2010).”
• The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance (2011, positive): “Hypoxia, mitophagy, and oxidative stress in HSC maintenance Normal quiescent HSCs are maintained in hypoxic niches, providing the optimal microenvironment to sustain their functions (Takubo et al., 2010).”
• Metabolic regulation of hematopoietic stem cells in the hypoxic niche. (2011, background): “Analysis of HSCs derived from conditional HIF-1a knockout (HIF-1aD/D) mice showed that they lost the capacity for marrow reconstitution during serial BM transplantation (Takubo et al., 2010).”
• Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. (2013, methodology): “Adult LT-HSCs are maintained in a hypoxic state in the bone marrow (BM) niche (Parmar et al., 2007; Takubo et al., 2010).”
• Hypoxia-Inducible Factors in Physiology and Medicine (2012, background): “…production of cartilage) (Schipani et al., 2001), adipogenesis (Yun et al., 2002), B lymphocyte development (Kojima et al., 2002), osteogenesis (Wang et al., 2007), hematopoiesis (Takubo et al., 2010), T lymphocyte differentiation (Dang et al., 2011), and innate immunity (Zinkernagel et al., 2007).”