Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

By Yi Guo, T. Walther, Meghana Rao, N. Stuurman, Gohta Goshima, K. Terayama, J. Wong, R. Vale, Peter Walter, Robert V Farese. Nature, 2008

716 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/673d70a7061e787a953ee554ebe315dd3f3fce46

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. T. Walther
2. Robert V Farese
3. R. Zechner
4. R. Coleman
5. M. Alves‐Bezerra
6. David E Cohen

In Molecular Biology

1. Jesse Stombaugh
2. Rob Knight
3. J. Rawls
4. T. Walther
5. Robert V Farese
6. R. Coleman
7. Noah Fierer
8. Micah Hamady

In Plant Science

1. Rob Knight

Citations in the corpus

• FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling (2012, neutral): “) melanogaster L2 cells (Beller et al., 2008; Guo et al., 2008).”
• Microbiota regulate intestinal absorption and metabolism of fatty acids in the zebrafish (2012, background): “Previous genetic analyses of LD formation have established that these dynamic organelles are under complex regulatory control and functionally linked to other cellular organelles and pathways (Guo et al., 2008; Beller et al., 2008).”
• PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores (2009, background): “Indeed, two groups have used genome-wide RNAi screens in Drosophila cells to discover an important role for the ARF-1/COPI trafficking system in the regulation of lipolysis [164,165].”
• Lipid Droplets And Cellular Lipid Metabolism (2012, background): “In Drosophila cells, LD fusion happens rarely except under specific conditions, such as PC deficiency (12, 41).”
• Arf Family G Proteins and their regulators: roles in membrane transport, development and disease (2011, background): “These proteins were identified in an RNAi screen of lipid droplet formation in D. melanogaster 23 and also appeared in proteomic analyses of lipid droplets along with other trafficking proteins, which led to the idea that lipid droplets interface with multiple membrane trafficking pathways 24 .”
• Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. (2013, background): “, 2010), but occurs frequently with PC deficiency or accumulation of phosphatidic acid (Fei et al., 2011; Guo et al., 2008).”
• Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores (2011, background): “melanogaster L2 cells for genes that affect LD size and morphology revealed that proteins of the ER-Golgi transport machinery are essential for normal LD number and size [118,119].”