Faculty Opinions recommendation of A role for the elongator complex in zygotic paternal genome demethylation.
By P. Geyer. 2010
143 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/668b5bff671c2c28f665dec8beacfae707091692
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In Molecular Biology
Citations in the corpus
- Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine (2011, methodology): “identified the elongator complex, and in particular its subunit Elp3, as a component required for zygotic DNA demethylation in the paternal pronucleus (33).”
- Epigenetic regulation of neurogenesis in the adult mammalian brain (2011, background): “, 2009c) and Radial SAM mechanisms involving the elongator complex (Okada et al., 2010).”
- 5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. (2011, methodology): “RNA interference knockdown of Tet proteins diminishes loss of 5mC Using an RNA interference-based strategy similar to the one described by Okada et al”
- Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions (2014, unknown): “Radical SAM Mechanisms Elongator complex protein 3 (ELP3) was reported to promote paternal genome demethylation in mouse zygotes (Okada et al., 2010).”
- A unique regulatory phase of DNA methylation in the early mammalian embryo (2012, background): “These observations may also support data suggesting the elongation factor/histone acetyltransferase ELP3 is a component of the DNA demethylation machinery and could explain a tight relationship between demethylation and transcription-associated complexes 50 .”
- Active DNA demethylation: many roads lead to Rome (2010, background): “However, GADD45B is not involved in zygotic DNA demethylation as GADD45B-null zygotes undergo normal paternal genome demethylatio”