A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA

By K. Ishii, C. Coban, H. Kato, Ken Takahashi, Yuichi Torii, F. Takeshita, H. Ludwig, G. Sutter, Koichi Suzuki, H. Hemmi and 6 more. Nature Immunology, 2006

835 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/6662892d18e963d01d46cadf715003fcd87542be

How researchers see this paper

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In Immunology

1. Shizuo Akira
2. Zhijian J. Chen
3. Taro Kawai
4. R. Medzhitov
5. O. Takeuchi
6. S. Ghosh
7. T. Mogensen
8. M. Hayden

Citations in the corpus

• 5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I (2009, background): “Genetic studies have shown that cytosolic DNA can induce IFN production in mouse cells lacking RIG-I or MAVS, suggesting that the DNA signaling pathway is distinct from the RIG-I pathway (Ishii et al., 2006; Sun et al., 2006).”
• Pattern Recognition Receptors and the Innate Immune Response to Viral Infection (2011, background): “production in human cells in a manner that was dependent on the RIG-I adapter molecule MAVS [52–54].”
• An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome (2009, background): “Although it has been known for decades that particular species of cytoplasmic RNA are immunostimulatory, the idea that cytoplasmic DNA can also elicit an innate immune response has emerged only recentl”
• The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling. (2014, background): “Cytosolic DNA induces type I IFNs through the endoplasmic reticulum membrane protein STING, which subsequently activates the transcription factors NF-kB and IRF3 through the kinases IKK and TBK1, respectively (Ishii et al., 2006; Ishikawa and Barber, 2008; Ishikawa et al., 2009; Stetson and Medzhito”
• RNA recognition and signal transduction by RIG‐I‐like receptors (2009, background): “Initially, host sensor molecules detect specific pathogen-associated molecular patterns (PAMPs) and activate the innate immune system through cytokine production including pro-inflammatory cytokines and type I interferons (IFNs).”
• Immune sensing of DNA (2013, neutral): “…pathways mediating type I IFN induction in response to cytosolic dsDNA, beginning with the definition of the key kinase complex and transcription factor activated by cytosolic DNA, namely TANK-binding kinase 1 (TBK1) and IRF3, respectively (Stetson and Medzhitov, 2006; Ishii et al., 2006).”
• Recognition of microorganisms and activation of the immune response (2007, background): “It is, however, clear that the RNA-sensing pathway and the DNA-sensing pathway converge on the protein kinase TBK1 (TANK-binding kinase 1) and the transcription factor IFN-regulatory factor 3 (refs”
• The innate immune DNA sensor cGAS produces a non-canonical cyclic-di-nucleotide that activates human STING (2013, background): “C The cytosolic presence of foreign double-stranded DNA (dsDNA) triggers a potent antiviral response dominated by the production of type I interferons (IFNs) (Ishii et al., 2006; Stetson and Medzhitov, 2006).”