The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling.

By Xin Cai, Y. Chiu, Zhijian J. Chen. Molecules and Cells, 2014

927 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/49827d45b5ae37550fa55c267288401971a3fe89

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Zhijian J. Chen
2. Tuo Li
3. Taro Kawai
4. A. West
5. Xiang Chen
6. G. Shadel
7. Shizuo Akira
8. Xiao-Dong Li

In Infectious Diseases

1. Tuo Li
2. Zhijian J. Chen
3. Xiang Chen
4. Taro Kawai

In Public Health, Environmental and Occupational Health

1. Tuo Li
2. Zhijian J. Chen
3. Taro Kawai

Citations in the corpus

• Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA (2014, background): “C They are produced after recognition of viral nucleic acids by toll-like receptors (TLRs) or by cytoplasmic proteins such as RIG-I-like receptors (RLRs) or the cyclic GMP-AMP synthase (cGAS) (Cai et al., 2014; Kawai and Akira, 2011; Loo and Gale, 2011).”
• Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases (2015, background): “cGAS binds to double-stranded DNA (dsDNA) in a sequence-independent manner (2, 7, 8).”
• Toll-Like Receptor Signaling Pathways (2014, background): “Mammals have several distinct classes of PRRs including Toll-like receptors (TLRs), RIG-I-like receptors (RLRs), Nodlike receptors (NLRs), AIM2-like receptors (ALRs), C-type lectin receptors (CLRs), and intracellular DNA sensors such as cGAS (2, 3).”