5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I

By A. Schmidt, T. Schwerd, W. Hamm, J. Hellmuth, S. Cui, Michaela Wenzel, F. Hoffmann, M. Michallet, R. Besch, K. Hopfner and 2 more. 2009

439 citations recorded by the source corpus.

Subfields: Immunology, Oncology

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Citations in the corpus

SF1 and SF2 helicases: family matters (2010, neutral): “However, RIG-I and related proteins also act on duplex RNA [19,70,82,83].”
ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA (2015, background): “RIG-I preferentially detects base-paired double-stranded RNA (dsRNA) ends containing either 5 triphosphate (ppp) or 5 diphosphate (pp) moieties (Goubau et al., 2014; Hornung et al., 2006; Pichlmair et al., 2006; Schlee et al., 2009; Schmidt et al., 2009) and not 2’ OH methylated at the”
Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants (2018, background): “Specifically, RIG-I detects dsRNA ends harbouring 5’ tri- or diphosphates (Goubau et al., 2014; Schlee et al., 2009; Schmidt et al., 2009).”
Pathogen Recognition by the Innate Immune System (2011, background): “It was thought that single-stranded RNAs bearing a 5′ triphosphate were the only essential component for this recognition [50, 51]; however, recent studies suggest that, during the enzymatic synthesis of RNA, a secondary structure for double stranded RNA is generated, which acts as a RIG-I ligand [5”
Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing (2010, background): “It is yet unclear whether ssRNA, even in the presence of a 5′-triphosphate group, is capable of inducingRIG-I activity, and at least in the case of shorter RNA molecules it appears that some double-stranded characteristics are required for its activation (12, 13).”
Pattern recognition receptors and inflammation. (2010, background): “However, recent studies have shown that T7 polymerase commonly produces extended byproducts generating dsRNA (Schlee et al., 2009; Schmidt et al., 2009).”
Cytosolic Sensing of Viruses (2013, background): “In addition to having a 50 monophosphate, the majority of genomes and antigenomes of BDV have a 30 overhang as a result of trimming of the 50 end, making them refractory to RIG-I detection (Schlee et al., 2009; Schmidt et al., 2009; Schneider et al., 2007).”
Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5 (2015, neutral): “They recognize RNA species harboring 5′-triphosphate or diphosphate ends and/or double-stranded features (dsRNA) [3–7] that are physiologically absent from the cytosol (see [2] for review).”
A structure-based model of RIG-I activation. (2012, background): “…minimal requirement for RIG-I activation is a blunt-ended basepaired RNA 10–20 bp long with a 59 triphosphate and free of mismatches near the blunt end (denoted 59pppbpRNA, since it could arise from ssRNA with complementary ends or dsRNA) (Schlee et al. 2009; Schmidt et al. 2009; Marq et al. 2010).”
Structural and functional insights into pattern recognition by the innate immune receptor RIG-I (2010, background): “More recently, two groups showed that RIG-I required base paired structures in conjunction with attached 5′-triphosphate to trigger antiviral signalin”