Obligate Role of Anti-Apoptotic MCL-1 in the Survival of Hematopoietic Stem Cells

By J. Opferman, H. Iwasaki, C. Ong, Heikyung Suh, S. Mizuno, K. Akashi, S. Korsmeyer. Science, 2005

613 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/66611c66dba9ae5df4655fba12f45422855ed2da

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In Immunology

Citations in the corpus

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production (2014, positive): “Deletion of prosurvival Mcl-1 leads to their death, whereas overexpression of Bcl-2 increases their number (Domen et al., 2000; Opferman et al., 2005).”
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. (2006, background): “Likewise, MCL-1 is absolutely required for IL-7-mediated survival of immature T and B cells as well as hematopoietic stem cells (Opferman et al., 2003, 2005).”
The Bcl-2 apoptotic switch in cancer development and therapy (2007, background): “…for the survival and implantation of the zygote (Rinkenberger et al., 2000), and its conditional elimination has revealed critical roles in B and T lymphopoiesis and early hematopoiesis (Opferman et al., 2003, 2005), as well as in mature neutrophils but not macrophages (Dzhagalov et al., 2006).”
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. (2005, background): “…(Opferman et al. 2003) would be attributable to the minimal levels of Bcl-xL found at particular stages of B- and T-cell development (Marsden and Strasser 2003), and the decimation of myeloid progenitor and stem cells deprived of Mcl-1 (Opferman et al. 2005) can be accounted for analogously.”
Cracking the BAFF code (2009, background): “MCL1 is a short-lived member of the B cell lymphoma 2 (BCL-2) family that is required for the development of haematopoietic stem cells and for the maintenance of peripheral B and T cell”
The BCL-2 Family Reunion (2010, background): “For example, mcl-1 deletion in the adult mouse revealed a requirement in hematopoietic stem cell survival, although it is not known if this is due to MCL-1’s antiapoptotic effects (Opferman et al., 2005).”
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. (2006, background): “Recent studies argue that Mcl-1 has a critical, distinctive role in the control of apoptosis (Cuconati et al., 2003; Nijhawan et al., 2003; Opferman et al., 2005).”